Macrophages and HIV-1
Macrophages and HIV-1
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DOI：
10.1097/coh.0b013e3283497203
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发表时间：
2011-09-01
影响因子：
4.1
通讯作者：
Kootstra, Neeltje A.
中科院分区：
文献类型：
--
作者：
Cobos-Jimenez, Viviana;Booiman, Thijs;Kootstra, Neeltje A.
巨噬细胞在HIV-1的致病过程中起着重要作用，并有助于建立负责持续病毒生产的病毒库。这篇综述将讨论HIV-1在巨噬细胞中感染以及感染对免疫功能和病理的影响的新见解。最新发现与HIV-1复制周期的各个步骤相互作用的新的细胞因子，如进入、整合、转录和组装新的病毒后代。细胞和病毒的microRNAs已被证明可以调节病毒复制，促进病毒潜伏，并延长细胞存活。HIV-1对先天免疫功能的干扰，如吞噬、自噬、细胞因子产生和T细胞激活，已被发现有助于病毒复制和潜伏。越来越多的证据表明，感染的巨噬细胞在包括神经认知障碍在内的各种HIV-1相关疾病中发挥着重要作用。摘要在联合抗逆转录病毒治疗(CART)下，HIV-1继续在巨噬细胞中存活。更好地了解巨噬细胞中HIV-1感染可能会导致新的辅助疗法来改善CART，特别是针对病毒库和改善组织特异性疾病。
Purpose of reviewMacrophages play an important role in HIV-1 pathogenesis and contribute to the establishment of the viral reservoir responsible for continuous virus production. This review will discuss new insights into HIV-1 infection in macrophages and the effect of infection on immune function and pathology.Recent findingsNew cellular factors interacting with various steps of the HIV-1 replication cycle, such as entry, integration, transcription, and assembly of new viral progeny, have been identified. Cellular and viral microRNAs have been shown to regulate virus replication, promote viral latency, and prolong cell survival. Interference with innate immune functions, like phagocytosis, autophagy, cytokine production, and T-cell activation by HIV-1 has been found to contribute to virus replication and latency. Growing evidence indicates an important role of infected macrophages in a variety of HIV-1-associated diseases, including neurocognitive disorders.SummaryUnder combined antiretroviral therapy (cART), HIV-1 continues to persist in macrophages. Better understanding of HIV-1 infection in macrophages may lead to new adjunctive therapies to improve cART, specifically targeting the viral reservoir and ameliorating tissue-specific diseases.