Regulation of Dynamic Protein S-Acylation.
Regulation of Dynamic Protein S-Acylation.
复制标题
DOI：
10.3389/fmolb.2021.656440
复制
发表时间：
2021
影响因子：
5
通讯作者：
Boehning D
中科院分区：
文献类型：
--
作者：
Chen JJ;Fan Y;Boehning D
蛋白质S-酰化是脂肪酸与靶蛋白的半胱氨酸残基的可逆加成。它调节蛋白质功能的多个方面，包括膜定位、细胞内运输、蛋白质相互作用、蛋白质稳定性和蛋白质构象。这一过程是由棕榈酰基转移酶，具有保守的氨基酸序列DHHC在其活性位点调节。虽然它们具有保守的催化核心，但DHHC酶在其蛋白质底物选择、脂质底物偏好和调节机制方面有所不同。DHHC酶功能的改变与许多人类疾病有关，包括癌症和神经系统疾病。酰基蛋白硫酯酶催化脂肪酸从酰化半胱氨酸残基的去除。值得注意的是，S-酰化现在已知是一个高度动态的过程，并在各种细胞类型的信号转导中起着至关重要的作用。在这篇综述中，我们将探讨蛋白质S-酰化的最新研究结果，这一过程的酶调节，并讨论动态S-酰化的例子。
Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions, protein stability, and protein conformation. This process is regulated by palmitoyl acyltransferases that have the conserved amino acid sequence DHHC at their active site. Although they have conserved catalytic cores, DHHC enzymes vary in their protein substrate selection, lipid substrate preference, and regulatory mechanisms. Alterations in DHHC enzyme function are associated with many human diseases, including cancers and neurological conditions. The removal of fatty acids from acylated cysteine residues is catalyzed by acyl protein thioesterases. Notably, S-acylation is now known to be a highly dynamic process, and plays crucial roles in signaling transduction in various cell types. In this review, we will explore the recent findings on protein S-acylation, the enzymatic regulation of this process, and discuss examples of dynamic S-acylation.
影响因子：
3.7
作者：
Kong C;Samovski D;Srikanth P;Wainszelbaum MJ;Charron AJ;Liu J;Lange JJ;Chen PI;Pan ZQ;Su X;Stahl PD
通讯作者：
Stahl PD