Control of effector CD8+ T cell function by the transcription factor Eomesodermin
Control of effector CD8+ T cell function by the transcription factor Eomesodermin
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DOI：
10.1126/science.1090148
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发表时间：
2003-11-07
期刊：
影响因子：
56.9
通讯作者：
Reiner, SL
中科院分区：
文献类型：
--
作者：
Pearce, EL;Mullen, AC;Reiner, SL
活化的CD 8（+）T细胞在宿主防御病毒、细胞内微生物和肿瘤中起关键作用。目前尚不清楚是否有一个关键的调节转录因子联合CD 8（+）T细胞的效应功能。我们现在表明，Eomesodermin（Eomes），T-bet的一个parastrin，诱导效应CD 8（+）T细胞在体外和体内。Eomes的异位表达足以激发效应CD 8（+）T细胞的属性，包括干扰素-γ（IFN-γ）、穿孔素和颗粒酶B。功能丧失分析表明Eomes也可能是CD 8（+）T细胞完全效应分化所必需的。我们认为，Eomesodermin是可能的补充行动的T-bet和作为一个关键的调控基因在细胞介导的免疫发展。
Activated CD8(+) T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8(+) T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8(+) T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8(+) T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8(+) T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.