Positive Selection Is Not Required for Thymic Maturation ofTransgenic ~8 T Cells
Positive Selection Is Not Required for Thymic Maturation ofTransgenic ~8 T Cells
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转基因 ~8 T 细胞的胸腺成熟不需要正选
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
E. Schweighoffer
中科院分区：
文献类型：
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作者：
E. Schweighoffer
Summary Previously published reports describing thymic differentiation in two TCtL~/8 transgenic mouse models have suggested that ~/8 T cells require MHC-mediated positive selection to reach full maturity. Recent studies indicate that recognition of antigen by mature ~/8 T cells is not MHC restricted, raising the issue of why developing ~/8 T cells would even require MHCdriven positive selection. Therefore, we have reinvestigated the requirements for development and selection in G8 "y8 T cell receptor (TCtL) transgenic mice. Analyses of absolute cell numbers, phenotypic subsets, and functional competence of thymic and peripheral G8 ~/~ T cells indicate that these cells can fully mature in class I MHC-deficient mice. Moreover, mixed bone marrow chimeras demonstrate that y5 T cells of mutant B2-microglobulin ([32m ~ origin are partially deleted in the presence of H-2d-bearing thymocytes (previously beheved to be the haplotype mediating positive selection). We conclude that there is no requirement for class I-like molecules for the maturation/development of these transgenic y8 T cells and that the differences in thymocyte phenotype and number observed are, instead, attributable to effects of clonal deletion.
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DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bruce,J;Symington,FW;McKearn,TJ;Sprent,J
通讯作者：
Sprent,J
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DOI：
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发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Weintraub,BC;Jackson,MR;Hedrick,SM
通讯作者：
Hedrick,SM
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影响因子：
1.3
作者：
Flaherty,L;Elliott,E;Tine,JA;Walsh,AC;Waters,JB
通讯作者：
Waters,JB
影响因子：
56.9
作者：
KOLLER, BH;MARRACK, P;SMITHIES, O
通讯作者：
SMITHIES, O