Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5.
Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5.
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急性风湿热免疫复合物的检测及其与HLA-B5的关系。
DOI：
10.1172/jci109643
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Pope
中科院分区：
文献类型：
--
作者：
S. Yoshinoya;R. Pope
本文应用五种免疫复合物放射免疫分析法，对45例急性风湿热患者的急性期和27例急性期后随访血清进行了检测。所有患者均发生急性多发性关节炎。一次检测在89%的急性期血清中检测到复合物，两次检测为51%，三次检测为29%，四次检测为7%。免疫复合物值在随访时显著降低，尽管一些异常持续存在。关节外表现与循环免疫复合物的发生之间没有相关性。通过循环免疫复合物测量，HLA-B5阳性者表现出显著更显著的免疫应答。这些数据表明，循环免疫复合物经常发生在急性风湿热的成人。与B5阴性患者相比，通过多种技术在B5阳性患者中检测到的免疫复合物的相对频率表明，这些患者中免疫复合物的形成具有遗传基础。
Employing five radioimmunoassays for immune complexes, the sera of 45 acute and 27 postacute follow-up sera from patients with acute rheumatic fever were examined. All patients experienced actue polyarthritis. Complexes were detected in 89% of acute-phase sera by one assay, 51% by two, 29% by three, and 7% by four. Immune complex values decreased significantly at followup, although some abnormalities persisted. There was no correlation between extra-articular manifestations and the occurrence of circulating immune complexes. Those positive for HLA-B5 demonstrated a significantly more pronounced immune response as measured by circulating immune complexes. The data indicate that circulating immune complexes occur frequently in adults with acute rheumatic fever. The relative frequency of immune complexes detected by multiple techniques in B5-positive, compared with B5-negative, patients suggests a genetic basis for the development of immune complexes in these patiemts.