Choose Your Own Adventure: The Role of Histone Modifications in Yeast Cell Fate.
Choose Your Own Adventure: The Role of Histone Modifications in Yeast Cell Fate.
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DOI：
10.1016/j.jmb.2016.10.018
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发表时间：
2017-06-30
影响因子：
5.6
通讯作者：
Green EM
中科院分区：
文献类型：
--
作者：
Jaiswal D;Turniansky R;Green EM
当酵母细胞受到波动环境的挑战时，信号网络激活分化程序，促进其个体或集体生存。这些程序包括减数分裂孢子形成的启动，丝状生长结构的形成和程序性细胞死亡途径的激活。这些不同的细胞命运的建立和维持是由大量的基因表达程序驱动的，这些基因表达程序促进了形态学和生理学的必要变化。虽然这些基因组重编程事件依赖于一个专门的转录因子网络，但一组不同的染色质调节因子，包括组蛋白修饰酶、染色质重塑剂和组蛋白变体，也发挥着重要作用。在这里，我们回顾了组蛋白修饰在启动细胞命运转变中的广泛功能，特别关注它们对控制伴随这些细胞命运的分化程序和染色质重组所需的关键基因表达的贡献。
When yeast cells are challenged by a fluctuating environment, signaling networks activate differentiation programs that promote their individual or collective survival. These programs include the initiation of meiotic sporulation, the formation of filamentous growth structures and the activation of programmed cell death pathways. The establishment and maintenance of these distinct cell fates are driven by massive gene expression programs that promote the necessary changes in morphology and physiology. While these genomic reprogramming events depend on a specialized network of transcription factors, a diverse set of chromatin regulators, including histone-modifying enzymes, chromatin remodelers and histone variants, also play essential roles. Here, we review the broad functions of histone modifications in initiating cell fate transitions, with particular focus on their contribution to the control of expression of key genes required for the differentiation programs and chromatin reorganization that accompanies these cell fates.