Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city
Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city
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DOI：
10.1007/s00439-004-1125-7
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发表时间：
2004-06-01
期刊：
影响因子：
5.3
通讯作者：
Fernández, JR
中科院分区：
文献类型：
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作者：
Bonilla, C;Shriver, MD;Fernández, JR
与欧洲血统的人群相比，西班牙裔和非洲裔美国人的肥胖风险更高，这一特征可能与来自美洲原住民和西非父母群体的遗传风险等位基因有关。然而，西非血统与肥胖相关特征之间的关系，如体重指数（BMI）、脂肪量（FM）和无脂量（FFM），以及与非裔美国妇女的骨矿物质密度（BMD）之间的关系直到最近才被报道。为了进一步评估祖先对身体组成表型的影响，我们研究了一个具有大量欧洲人、西非人和美洲原住民混合的西班牙裔人群。我们确定了一个居住在纽约的波多黎各妇女样本（n=64），我们测量了她们的BMI和身体组成变量，如FM、FFM、体脂百分比和骨密度。此外，通过反射光谱法测量皮肤色素沉着作为黑色素指数。我们对35个常染色体祖先信息标记进行了基因分型，并根据欧洲、西非和美洲原住民对该人群的贡献估计了群体和个体祖先的比例。三个亲本群体对应的祖先比例分别为：欧洲人53.3+/-2.8%，西非人29.1+/-2.3%，美洲原住民17.6+/-2.4%。我们通过许多不同的测试在这个人群中发现了显著的遗传结构。皮肤色素沉着与个体血统有极显著的相关性(R-2=0.597， P
Hispanic and African American populations exhibit an increased risk of obesity compared with populations of European origin, a feature that may be related to inherited risk alleles from Native American and West African parental populations. However, a relationship between West African ancestry and obesity-related traits, such as body mass index (BMI), fat mass (FM), and fat-free mass (FFM), and with bone mineral density (BMD) in African American women has only recently been reported. In order to evaluate further the influence of ancestry on body composition phenotypes, we studied a Hispanic population with substantial European, West African, and Native American admixture. We ascertained a sample of Puerto Rican women living in New York (n=64), for whom we measured BMI and body composition variables, such as FM, FFM, percent body fat, and BMD. Additionally, skin pigmentation was measured as the melanin index by reflectance spectroscopy. We genotyped 35 autosomal ancestry informative markers and estimated population and individual ancestral proportions in terms of European, West African, and Native American contributions to this population. The ancestry proportions corresponding to the three parental populations are: 53.3+/-2.8% European, 29.1+/-2.3% West African, and 17.6+/-2.4% Native American. We detected significant genetic structure in this population with a number of different tests. A highly significant correlation was found between skin pigmentation and individual ancestry (R-2=0.597, P