Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease.
Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease.
复制标题
DOI：
10.1002/wsbm.1367
复制
发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Zangi L
中科院分区：
文献类型：
--
作者：
Hadas Y;Katz MG;Bridges CR;Zangi L
缺血性心脏病（IHD）是发达国家发病率和死亡率的主要原因。目前的药物治疗和介入治疗显著改善了患者的生活质量，但大多数是针对性的，而不是治愈性的。IHD的高疾病和经济负担要求寻找新的治疗策略以显著改善患者的预后和生活质量。IHD期间的主要挑战之一是具有最小再生能力的心肌细胞的大量损失。近年来对缺血性心脏病的病理生理机制的研究以及新的治疗方法为缺血性心脏病患者带来了新的希望。合成修饰的mRNA（modRNA）是一种新型的基因递送载体，越来越多地用于体内应用。modRNA是一种相对稳定的、非免疫原性的、高表达的分子，已显示其在不同类型的细胞和组织（包括心肌细胞）中介导蛋白质的高和瞬时表达。modRNA的特性及其在心脏中的表达动力学使其成为治疗IHD的有吸引力的选择，特别是在心肌梗死后。在这篇综述中，我们讨论了基因治疗在心脏再生中的作用，作为一种治疗IHD的方法;传统和创新的基因递送方法;并特别关注modRNA结构，递送模式及其用于诱导内源性再生能力的用途，主要是在IHD的背景下。
Ischemic heart disease (IHD) is a leading cause of morbidity and mortality in developed countries. Current pharmacological and interventional therapies provide significant improvement in the life quality of patient; however, they are mostly symptom-oriented and not curative. A high disease and economic burden of IHD requires the search for new therapeutic strategies to significantly improve patients’ prognosis and quality of life. One of the main challenges during IHD is the massive loss of cardiomyocytes that possess minimal regenerative capacity. Recent understanding of the pathophysiological mechanisms underlying IHD, as well as new therapeutic approaches provide new hope for patients suffering from IHD. Synthetic modified mRNA (modRNA) is a new gene delivery vector that is increasingly used in in vivo applications. modRNA is a relatively stable, non-immunogenic, highly-expressed molecule that has been shown to mediate high and transient expression of proteins in different type of cells and tissues including cardiomyocytes. modRNA properties, together with its expression kinetics in the heart make it an attractive option for the treatment of IHD, especially after myocardial infarction. In this review we discuss the role of gene therapy in cardiac regeneration as an approach to treat IHD; traditional and innovative gene delivery methods; and focus specifically on modRNA structure, mode of delivery, and its use for the induction of endogenous regenerative capacity, mainly in the context of IHD.
登录
查看更多内容
影响因子：
20.1
作者：
Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
13.2
作者：
Hekele, Armin;Bertholet, Sylvie;Archer, Jacob;Gibson, Daniel G.;Palladino, Giuseppe;Brito, Luis A.;Otten, Gillis R.;Brazzoli, Michela;Buccato, Scilla;Bonci, Alessandra;Casini, Daniele;Maione, Domenico;Qi, Zhi-Qing;Gill, John E.;Caiazza, Nicky C.;Urano, Jun;Hubby, Bolyn;Gao, George F.;Shu, Yuelong;De Gregorio, Ennio;Mandl, Christian W.;Mason, Peter W.;Settembre, Ethan C.;Ulmer, Jeffrey B.;Venter, J. Craig;Dormitzer, Philip R.;Rappuoli, Rino;Geall, Andrew J.
通讯作者：
Geall, Andrew J.
影响因子：
64.8
作者：
Hemmi, H;Takeuchi, O;Akira, S
通讯作者：
Akira, S
影响因子：
4.9
作者：
Huang, Chien-Ling;Leblond, Anne-Laure;Caplice, Noel M.
通讯作者：
Caplice, Noel M.