Anti-diabetic activity of methanol/methylene chloride stem bark extracts of Terminalia superba and Canarium schweinfurthii on streptozotocin-induced diabetic rats
Anti-diabetic activity of methanol/methylene chloride stem bark extracts of Terminalia superba and Canarium schweinfurthii on streptozotocin-induced diabetic rats
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DOI：
10.1016/j.jep.2005.08.075
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发表时间：
2006-04-06
影响因子：
5.4
通讯作者：
Dimo, T
中科院分区：
文献类型：
--
作者：
Kamtchouing, P;Kahpui, SM;Dimo, T
诃子茎皮提取物。以及Diels和橄榄Canarium schweinfurthii Engl.在非洲被用于治疗各种疾病，包括糖尿病。用链脲佐菌素（STZ）诱导的雄性大鼠糖尿病模型，观察了黄柏甲醇/二氯甲烷提取物的抗糖尿病作用。通过皮下途径，使用60 mg/mL链脲佐菌素诱导糖尿病。2天后，大鼠通过管饲法每天接受150 mg/kg和300 mg/kg的提取物，持续14天。在300 mg/kg剂量下，两种提取物（Terminalia superba和Canarium schweinfurthii）分别显著降低血糖水平至少67.1%和69.9%，而胰岛素（3个单位）皮下给药和每日一次，与糖尿病未治疗对照大鼠相比降低76.8%。同样，体重增加分别为6.6%和4.9%，与正常大鼠相当，而糖尿病未治疗大鼠体重减轻14.1%。仍然在相同剂量下，用相应植物提取物处理的糖尿病大鼠的食物消耗量显著减少68.5%和58.5%（p < 0.001），液体摄入量显著减少79.7%和64.0%（p < 0.001）。在实验的第二周结束时，胰岛素处理的大鼠显示食物和液体摄入量分别减少56.4%和75.8%，而糖尿病对照大鼠分别增加43.0%和383.8%。这些结果表明，植物提取物可以逆转由链脲佐菌素引起的高血糖、多食和烦渴，因此，它们具有抗糖尿病特性。(c)2005年爱思唯尔爱尔兰有限公司。保留所有战斗。
Stem bark extracts of Terminalia superba Engl. and Diels and Canarium schweinfurthii Engl. are used in Africa for the treatment of various ailments, including diabetes mellitus. The anti-diabetic effects of the methanol/methylene chloride extracts of the stem barks on streptozotocin (STZ)-induced diabetes were evaluated on male rats. Through the subcutaneous route, diabetes was induced using 60 mg/mL of streptozotocin. After 2 days, the rats received, by gavage, 150 mg/kg and 300 mg/kg of extract daily for 14 days. At 300 mg/kg, the two extracts (Terminalia superba and Canarium schweinfurthii), significantly showed at least 67.1% and 69.9% reduction in blood glucose level, respectively, while insulin (three units) given subcutaneously and once daily, had 76.8% reduction compared to diabetic untreated control rats. Similarly, the weight gains were 6.6% and 4.9%, respectively, and were comparable to the normal rats, whereas, diabetic untreated rats lost 14.1% body weight. Still with the same dose, there was 68.5% and 58.5% (p < 0.001) significant decrease in food consumption and 79.7% and 64.0% (p < 0.001) in fluid intake by diabetic rats treated with the respective plant extracts. The insulin-treated rats showed 56.4% and 75.8% decrease in food and fluid intake compared to an augmentation for diabetic control rats, 43.0% and 383.8%, respectively, at the end of the second week of experimentation. These results showed that the plant extracts can reverse hyperglycemia, polyphagia and polydipsia provoked by streptozotocin, and thus, they have anti-diabetic properties. (c) 2005 Elsevier Ireland Ltd. All fights reserved.