Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo-猫眼课题宝

DOI：

10.21873/invivo.12252

发表时间：

2021

期刊：

In Vivo

影响因子：

2.3

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

H. Yanagie;T. Fujino;M. Yanagawa;T. Terao;T. Imagawa;Mitsuteru Fujihara;Y. Morishita;R. Mizumachi;Y. Murata;N. Dewi;Yuuya Ono;I. Ikushima;K. Seguchi;M. Nagata;Y. Nonaka;Y. Furuya;T. Hisa;T. Nagasaki;K. Arimori;T. Nakashima;T. Sugihara*;K. Kakimi;M. Ono;J. Nakajima;M. Eriguchi;S. Higashi;Hiroyuki Takahashi

背景/目的：抗癌药物与碘化罂粟籽油（IPSO）混合用于肝细胞癌动脉化疗已被广泛应用。然而，抗癌药物很容易从IPSO中分离出来，因此治疗潜力有限。采用双膜乳化技术制备了表柔比星包水乳液（WOW-Epi）。材料与方法：经肝动脉注射WOW-Epi给VX2兔肝肿瘤模型（1.2 mg/kg）。结果：与对照组相比，wow - epi治疗组可选择性抑制VX2肿瘤生长。电镜证实了WOW在癌细胞附近的积累。内吞作用似乎是摄取WOW的机制。结论：WOW-Epi在体内抑制肿瘤生长。WOW不会对动脉血管产生毒性。在不久的将来，WOW-Epi有望用于HCC患者的动脉内重复化疗。

Background/Aim: A mixture of anticancer agents and iodized poppy seed oil (IPSO) has been widely used for intra-arterial chemotherapy of hepatocellular carcinoma. However, the anticancer agents can easily separate from IPSO, so the therapeutic potential is limited. We developed epirubicin-entrapped water-in-oil-in-water emulsion (WOW-Epi) using a double-membrane emulsification technique. Materials and Methods: We delivered WOW-Epi through a hepatic arterial injection to VX2 hepatic tumor rabbit model (1.2 mg/kg). Results: VX2 tumor growth was selectively suppressed in the WOW-Epi-treated group compared with the control treated groups. The accumulation of WOW in nearby cancer cells was confirmed via electron-microscopy. Endocytosis seemed to be the mechanism underlying the uptake of WOW. Conclusion: WOW-Epi led to tumour growth suppression in vivo. WOW does not cause toxicity to arterial vessels. WOW-Epi will be hopefully used for repeated intra-arterial chemotherapy to HCC patients in the near future.

Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo

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