Neuronal Synaptic Connections Organized by Small Numbers of Molecules.
Neuronal Synaptic Connections Organized by Small Numbers of Molecules.
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由少量分子组织的神经元突触连接。
DOI：
10.1007/978-981-13-2083-5_2
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Murakoshi H.
中科院分区：
文献类型：
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作者：
Shiratsuchi;A.;Ariki;S.;Kidoura;Y.;Hasegawa;H.;and Nakanishi;Y.;Murakoshi H.
19世纪80年代末，西班牙神经解剖学家圣地亚哥·拉蒙·卡哈尔(Santiago Ramón y Cajal，1852-1934)绘制了多幅细胞草图。在掌握了高尔基的方法(硝酸银和重铬酸钾反应形成的银铬酸盐沉积在组织的一部分细胞中)后，卡哈尔渴望展示脑组织中各种神经细胞的形态。这种方法是由比他大大约10岁的卡米洛·高尔基开发的。看看其中的一个(图1，左)。你怎么看？当时，一种理论认为神经细胞膜彼此相连(网状结构理论；图1，中间)；而另一种理论，神经元理论，认为神经细胞是离散的、不相连的单元(图1，右)。这两种理论的支持者之间展开了激烈的辩论。高尔基发展了他的同名染色方法，他支持网状结构理论，而他的学生卡哈尔支持神经元理论。他们中哪一个是正确的？图1(左)卡哈尔的大脑皮层示意图。(摘自参考文献[3]图66)。(中)网状结构理论。所有的电池都是相连的，有相同的内部液体。(右)神经元理论。单独的细胞被隔开
In the late 1880s, Spanish neuroanatomist Santiago Ramón y Cajal (1852–1934) drew multiple sketches of cells. Having mastered Golgi’s method (in which silver chromate formed by reacting silver nitrate and potassium dichromate is deposited in cells in “a part” of tissue), which was developed by Camillo Golgi, who was about 10 years his senior, Cajal aspired to demonstrate various neural cell morphologies in brain tissue. Have a look at one of them (Fig. 1, left). What do you think? At that time, one theory held that the membranes of neural cells bordered on each other and were connected (the reticular theory; Fig. 1, middle); while another theory, the neuron theory, held that neural cells were discrete, unconnected units (Fig. 1, right). A great debate raged between supporters of these two theories. Golgi, who developed his eponymous staining method, endorsed the reticular theory, while his pupil Cajal supported the neuron theory. Which of them is correct? Fig. 1(Left) Sketch of the cerebral cortex by Cajal. (From Ref. [3], Fig. 66). (Middle) The reticular theory . All cells are connected and have the same internal fluid. (Right) The neuronal theory . Individual cells are compartmentalized