Effect of conjugated linoleic acid, vitamin E and their combination on lipid profiles and blood pressure of Iranian adults with active rheumatoid arthritis.
Effect of conjugated linoleic acid, vitamin E and their combination on lipid profiles and blood pressure of Iranian adults with active rheumatoid arthritis.
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DOI：
10.2147/vhrm.s3822
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发表时间：
2008
影响因子：
2.9
通讯作者：
Zarei M
中科院分区：
文献类型：
--
作者：
Aryaeian N;Shahram F;Djalali M;Eshragian MR;Djazayeri A;Sarrafnejad A;Naderi N;Chamari M;Fatehi F;Zarei M
本研究的目的是评估共轭亚油酸 (CLA)、维生素 E 以及这些营养素的组合对活动性类风湿关节炎 (RA) 患者血脂和血压 (BP) 的影响。在一项随机、双盲、安慰剂对照试验中，87 名活动性 RA 患者被分为四组，接受以下每日补充剂之一，持续三个月：C 组：CLAs 2.5 g，相当于 2 g 顺式 9-反式 11 和反式 10-cis12 CLA 的混合物，比例为 50/50； E组：维生素E：400毫克； CE 组：以上剂量的 CLA 和维生素 E：P 组：安慰剂。补充后，与E组和P组相比，C组的SBP水平显着降低，C组和CE组的平均动脉压显着降低。各组间前列腺素E2（PGE2）、甘油三酯、胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、LDL/HDL、胆固醇/HDL、空腹血糖、C反应蛋白（CRP）、芳酯酶活性、血小板计数和体重指数水平无显着差异。 P、C、E 和 CE 组的 CRP 无显着下降（分别为 19%、24%、55% 和 39%）。 C、E 和 CE 组的红细胞沉降率水平降低（分别为 P ≤ 0.05、P ≤ 0.05、P ≤ 0.001）。结论是补充 CLA 可以降低血压，补充维生素 E 可以降低 CRP。因此，共同补充 CLA 和维生素 E 可能有益于 RA 患者的心脏病预防。
The aim of this study was to assess the impact of conjugated linoleic acids (CLAs), vitamin E, and combination of these nutrients on serum lipid profiles and blood pressure (BP) in patients with active rheumatoid arthritis (RA). In a randomized, double-blind, placebo-controlled trial, 87 patients with active RA were divided into four groups receiving one of the following daily supplements for three months: Group C: CLAs 2.5 g equivalent to 2 g mixture of cis 9-trans 11 and trans 10-cis12 CLAs in a rate of 50/50; Group E: vitamin E: 400 mg; Group CE: CLAs and vitamin E at above doses: Group P: placebo. After supplementation, SBP levels decreased significantly in the group C in comparison with groups E and P and mean arterial pressure reduced significantly in groups C and CE. There weren’t significant differences in the levels of prostaglandin E2 (PGE2), triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL/HDL, cholesterol/HDL, fasting blood sugar, C-reactive protein (CRP), arylestrase activity, platelet count and body mass index between groups. CRP dropped nonsignificantly in groups P, C, E and CE (19%, 24%, 55%, and 39%, respectively). Erythrocytes sedimentation rate levels decreased in groups C, E and CE (P ≤ 0.05, P ≤ 0.05, P ≤ 0.001, respectively). It is concluded that supplementation of CLAs decreased BP and vitamin E decreased CRP. Therefore cosupplementation of CLAs and vitamin E might be profitable for heart disease prevention in RA patients.