Bone-marrow-derived mononuclear cells with a porous hydroxyapatite scaffold for the treatment of osteonecrosis of the femoral head A PRELIMINARY STUDY
Bone-marrow-derived mononuclear cells with a porous hydroxyapatite scaffold for the treatment of osteonecrosis of the femoral head A PRELIMINARY STUDY
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DOI：
10.1302/0301-620x.92b3.22483
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发表时间：
2010-03-01
影响因子：
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通讯作者：
Ochi, M.
中科院分区：
文献类型：
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作者：
Yamasaki, T.;Yasunaga, Y.;Ochi, M.
我们探讨了骨髓来源的单个核细胞(BMMNCs)复合多孔羟基磷灰石(IP-CHA)移植治疗股骨头坏死的早期骨修复效果。我们研究了22名患者(30个髋关节)，他们在植入骨髓单个核细胞后至少获得了一年的随访。手术时平均年龄41岁(18岁)，随访19~48个月，平均29个月。在对照组中，另外8名股骨头坏死患者(9个髋关节)植入了无细胞IP-CHA，并对结果进行了比较。在BMMNC组，由于移行区骨质肥大，骨坏死病变的大小有所缩小。在治疗组的三名患者中，检测到进展为广泛性崩溃。在对照组，8个髋关节中有6个股骨头严重塌陷。在这项有限的研究中，植入BMNCs和IP-CHA似乎有利于骨坏死的修复和防止塌陷。
We have investigated the effectiveness of the transplantation of bone-marrow-derived mononuclear cells (BMMNCs) with interconnected porous calcium hydroxyapatite (IP-CHA) on early bone repair for osteonecrosis of the femoral head. We studied 22 patients (30 hips) who had osteonecrosis with a minimum follow-up of one year after implantation of BMMNCs. The mean age at surgery was 41 years (18 to 64) and the mean period of follow-up was 29 months (19 to 48). In a control group, cell-free IP-CHA was implanted into a further eight patients (9 hips) with osteonecrosis of the femoral head and the outcomes were compared.A reduction in the size of the osteonecrotic lesion was observed subsequent to hypertrophy of the bone in the transition zone in the BMMNC group. In three patients in the treatment group progression to extensive collapse was detected. In the control group subtle bone hypertrophy was observed, but severe collapse of the femoral head occurred in six of eight hips.In this limited study the implantation of BMMNCs and IP-CHA appears to confer benefit in the repair of osteonecrosis and in the prevention of collapse.