Mechanism by which bacterial flagellin stimulates host mucin production.
Mechanism by which bacterial flagellin stimulates host mucin production.
复制标题
细菌鞭毛蛋白刺激宿主粘蛋白产生的机制。
DOI：
10.1007/978-1-4615-0717-8_37
复制
发表时间：
2002
影响因子：
--
通讯作者：
Basbaum,Carol
中科院分区：
文献类型：
--
作者：
McNamara,Nancy;Basbaum,Carol
In their quest to colonize and infect host tissues, bacteria cause considerable damage to their hosts. Based on this, an evolutionary trend has occurred for host organisms to develop defense mechanisms against bacteria. One is mucin production. Mucin is a high molecular weight glycoprotein synthesized by non-keratinized epithelial cells at the boundary of the host with its environment. The size of a single mucin monomer can be as large as 1 million daltons, most of which is composed of carbohydrate residue. Mucin molecules polymerize by disulfide bonds and electrostatic interactions to form a viscoelastic gel that effectively augments the barrier between host and bacteria. In the respiratory tract, bacteria-laden mucus is conducted toward the throat by cilia and then either swallowed or expectorated. In the eye, bacteria-laden mucus is cleared by blinking.
