Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients
Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients
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DOI：
10.1016/j.niox.2014.10.007
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发表时间：
2015-08-01
影响因子：
3.9
通讯作者：
Miller, Gary D.
中科院分区：
文献类型：
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作者：
Berry, Michael J.;Justus, Nicholas W.;Miller, Gary D.
通过甜菜根汁补充饮食中的硝酸盐（NO3-）已被证明可以提高年轻人和老年人的运动能力。本研究旨在探讨急性NO3-摄入对慢性阻塞性肺疾病（COPD）患者亚极量恒定速率运动能力的影响。15名患者被随机分配，单盲，交叉设计，接受两种治疗之一（甜菜根汁，然后安慰剂或安慰剂，然后甜菜根汁）。以患者最大工作能力的75%进行的次最大恒定功率运动时间是主要结局。次要结局包括血浆NO3-和亚硝酸盐（NO2-）水平、血压、心率、耗氧量（VO 2）、动态过度充气、呼吸困难和腿部不适。与安慰剂相比，甜菜根摄入使血浆NO3-增加了938%，NO2-增加了379%。与安慰剂相比，摄入甜菜根后的中位（+四分位距）运动时间显著更长（p = 0.031）（分别为375.0 ± 257.0秒和346.2 ± 148.0秒）。与安慰剂相比，甜菜根摄入显著降低了iso-time（p = 0.001）和运动结束（p = 0.008）舒张压分别为6.4和5.6 mmHg。甜菜根与安慰剂试验相比，静息收缩压显著降低（p = 0.019）82 mmHg。甜菜根和安慰剂试验之间没有其他变量有显著差异。这些结果表明，急性膳食NO3-补充剂可以提高血浆NO3-和NO2-浓度，改善运动能力，降低COPD患者的血压。(C)2014爱思唯尔公司All rights reserved.
Dietary nitrate (NO3-) supplementation via beetroot juice has been shown to increase the exercise capacity of younger and older adults. The purpose of this study was to investigate the effects of acute NO3- ingestion on the submaximal constant work rate exercise capacity of COPD patients. Fifteen patients were assigned in a randomized, single-blind, crossover design to receive one of two treatments (beetroot juice then placebo or placebo then beetroot juice). Submaximal constant work rate exercise time at 75% of the patient's maximal work capacity was the primary outcome. Secondary outcomes included plasma NO3- and nitrite (NO2-) levels, blood pressure, heart rate, oxygen consumption (VO2), dynamic hyperinflation, dyspnea and leg discomfort. Relative to placebo, beetroot ingestion increased plasma NO3- by 938% and NO2- by 379%. Median (+interquartile range) exercise time was significantly longer (p = 0.031) following the ingestion of beetroot versus placebo (375.0 + 257.0 vs. 346.2 + 148.0 s, respectively). Compared with placebo, beetroot ingestion significantly reduced iso-time (p = 0.001) and end exercise (p = 0.008) diastolic blood pressures by 6.4 and 5.6 mmHg, respectively. Resting systolic blood pressure was significantly reduced (p = 0.019) by 82 mmHg for the beetroot versus the placebo trial. No other variables were significantly different between the beetroot and placebo trials. These results indicate that acute dietary NO3- supplementation can elevate plasma NO3- and NO2- concentrations, improve exercise performance, and reduce blood pressure in COPD patients. (C) 2014 Elsevier Inc. All rights reserved.