FREQUENCIES OF SYNONYMOUS SUBSTITUTIONS IN MAMMALS ARE GENE-SPECIFIC AND CORRELATED WITH FREQUENCIES OF NONSYNONYMOUS SUBSTITUTIONS
FREQUENCIES OF SYNONYMOUS SUBSTITUTIONS IN MAMMALS ARE GENE-SPECIFIC AND CORRELATED WITH FREQUENCIES OF NONSYNONYMOUS SUBSTITUTIONS
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DOI：
10.1007/bf00166602
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发表时间：
1995-01-01
影响因子：
3.9
通讯作者：
BERNARDI, G
中科院分区：
文献类型：
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作者：
MOUCHIROUD, D;GAUTIER, C;BERNARDI, G
哺乳动物基因同义替换的频率比以前认为的覆盖范围更广。我们在这里报告说，在同源基因中发现的不同频率从一个给定的哺乳动物对与那些在相同的同源基因从不同的哺乳动物对。这表明同义替换的频率是基因特异性的（非同义替换的频率也是如此），或者换句话说，一种哺乳动物中的“快"和”慢“基因在任何其他哺乳动物中分别是快的和慢的。此外，同义替换的频率与相同基因中的非同义替换的频率相关。
The frequencies of synonymous substitutions of mammalian genes cover a much wider range than previously thought. We report here that the different frequencies found in homologous genes from a given mammalian pair are correlated with those in the same homologous genes from a different mammalian pair. This indicates that the frequencies of synonymous substitutions are gene-specific (as are the frequencies of nonsynonymous substitutions), or, in other words, that ''fast'' and ''slow''' genes in one mammal are fast and slow, respectively, in any other one. Moreover, the frequencies of synonymous substitutions are correlated with the frequencies of nonsynonymous substitution in the same genes.