REGENERATING MARROW INDUCES SYSTEMIC INCREASE IN OSTEOGENESIS AND CHONDROGENESIS
REGENERATING MARROW INDUCES SYSTEMIC INCREASE IN OSTEOGENESIS AND CHONDROGENESIS
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DOI：
10.1210/endo-126-5-2607
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发表时间：
1990-05-01
期刊：
影响因子：
4.8
通讯作者：
BAB, I
中科院分区：
文献类型：
--
作者：
GAZIT, D;KARMISH, M;BAB, I
长骨的骨髓消融诱导远处骨骼部位骨生成增加。为了测试骨髓再生在这一现象中的作用，在胫骨骨髓消融后愈合期间和愈合抑制后，对大鼠下颌骨髁状突进行组织形态计量学评价。去除胫骨骨髓后10天，髁突软骨下骨的所有骨形成参数均显著升高，表明成骨细胞活性增强。钙化软骨区的厚度也增加。当胫骨消融后愈合受到抑制时和大面积肝损伤后，这些变化不存在。广泛的骨膜损伤只引起成骨细胞活性的轻微增加。除第7天下降外，髁突软骨和口腔粘膜中的[甲基-3H]胸苷标记指数在消融后3-18天保持在对照水平。这些发现意味着刺激细胞增殖在骨骼对骨髓消融的反应中仅起次要作用。它的结论是，在骨髓再生过程中优先发生的全身性骨生成的增加，是不是一个非特异性的骨骼组织损伤的反应。显然，全身性成骨反应是由愈合骨髓产生的循环因子介导的;从概念上讲，它与其他情况有关，即皮肤外部位的局部修复伴随着相应组织的全身性改变。
Marrow ablation in long bones induces an increase in osteogenesis in distant skeletal sites. To test the role of marrow regeneration in this phenomenon, rat mandibular condyles were evaluated histomorphometrically during postablation healing of tibial marrow and after inhibition of healing. Ten days after removal of tibial marrow all bone formation parameter in the condylar subchondral bone were markedly elevated, indicating an enhanced osteoblastic activity. The thickness of the cartilaginous zone of calcification was also augmented. These changes were absent when postablation healing was inhibited in the tibia and after massive liver injury. Extensive periosteal injury induced only a slight increase in osteoblast activity. Except for a fall on day 7, the [methyl-3H]thymidine labeling index in the condylar cartilage and oral mucosa remained at control levels 3-18 days after ablation. These findings imply that stimulation of cell proliferation has only a secondary role in the skeletal response to marrow ablation. It is concluded that the systemic increase in osteogenesis occurs preferentially during marrow regeneration and is not a nonspecific skeletal reaction to tissue injury. Apparently, the systemic osteogenic response is mediated by circulating factors produced by the healing marrow; conceptually it is related to other instances where local repair in extraskeletal sites is accompanied by generalized alterations in respective tissues.