Characterization of the immune response to collagen-like proteins Scl1 and Scl2 of serotype M1 and M28 group A Streptococcus.
Characterization of the immune response to collagen-like proteins Scl1 and Scl2 of serotype M1 and M28 group A Streptococcus.
复制标题
对血清型 M1 和 M28 A 组链球菌的胶原蛋白样蛋白 Scl1 和 Scl2 的免疫反应的表征。
DOI：
10.1111/j.1574-6968.2007.00955.x
复制
发表时间：
2007
影响因子：
2.1
通讯作者：
Lukomski,Slawomir
中科院分区：
文献类型：
--
作者：
Hoe,NancyP;Lukomska,Ewa;Musser,JamesM;Lukomski,Slawomir
Group AStreptococcus(GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS.
