Biphasic effect of arsenic on cell growth and its clinical significance

Biphasic effect of arsenic on cell growth and its clinical significance
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砷对细胞生长的双相效应及其临床意义

DOI:
10.24015/2167-7700.8.264
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发表时间:
2019
期刊:
Chemotherapy: Open Access
影响因子:
--
通讯作者:
Kewei Wang
Kewei Wang
中科院分区:
其他
文献类型:
--
作者:
Dianjun Sun;Kewei Wang

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砷在低浓度下刺激增殖,在高浓度下抑制细胞生长,对生物过程表现出双相效应。双相效应要求化疗期间砷浓度必须维持在适当的阈值。细胞凋亡可能是与砷的双重特性相关的主要机制。关键词:砷;双相效应;地方性砷中毒;致癌作用;化疗。
Arsenic stimulates proliferation at low levels and inhibits cell growth at high concentrations, showing a biphasic effect on biological process. The biphasic effect requires that arsenic concentration has to be maintained at an appropriate threshold during chemotherapy. The apoptosis may be a primary mechanism related to dual properties of the arsenic. Keywords: Arsenic; Biphasic effect; Endemic arsenism; Carcinogenesis; Chemotherapy.
DOI: --
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