IgM antibodies in hospitalized children with febrile illness during an inter-epidemic period of measles, in Somalia
IgM antibodies in hospitalized children with febrile illness during an inter-epidemic period of measles, in Somalia
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DOI：
10.1016/s1386-6532(98)00002-x
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发表时间：
1999-01-01
影响因子：
8.8
通讯作者：
Osterhaus, ADME
中科院分区：
文献类型：
--
作者：
Nur, YA;Groen, J;Osterhaus, ADME
背景：在世界卫生组织扩大免疫规划认可的消除麻疹计划的背景下，识别可能与麻疹混淆的感染是一个重大挑战。目的：确定索马里一家医院麻疹流行间歇期儿童发热性疾病的原因。研究设计：对23名索马里发热性疾病儿童和23名年龄匹配的儿童进行血清学试验，以检测麻疹病毒、腮腺炎病毒、风疹病毒、人类疱疹病毒6型、Epstein Barr病毒、微小病毒B19、登革热病毒、结果：在约1/3的发热性疾病中，病毒、支原体和立克次体可被确定为可能的致病原因。结论：虽然在需要住院的儿童中，发热皮疹通常被认为是由麻疹引起的，但在鉴别诊断时，还有其他几个重要的病毒学原因需要考虑。此外，如果要消除这种疾病，人们越来越需要开发一种简单、敏感、特异和随时可用的检测方法来识别每个麻疹病例。(C)1999 Elsevier Science B.V.保留所有权利。
Background: In the context of the measles elimination programme, endorsed by the expanded programme on immunization of the World Health Organization, the identification of infections which may be confused with measles is a major challenge.Objective: To determine the causes of febrile illness in children in an inter-epidemic period of measles in a Somalian hospital.Study design: Serological tests were performed on sera from 23 Somali children with febrile illness and from 23 age matched children, to measure the specific IgM and IgG antibodies against measles virus, mumps virus, rubella virus, human herpes-6 virus, Epstein Barr virus, parvovirus B19, dengue virus, Mycoplasma pneumoniae and Rickettsia conorii.Results: In about one third of the cases of febrile illness viral, mycoplasmal and rickettsial agents could be identified serologically as the probable cause of the disease.Conclusions: Although febrile illness with rash in children needing hospitalization is usually assumed to be due to measles, there are several other important virological causes of this condition which need to be considered in the differential diagnosis. Moreover there is a growing need to develop a simple, sensitive, specific and ready to use test to identify each case of measles, if this disease is to be eliminated. (C) 1999 Elsevier Science B.V. All rights reserved.