Development and testing of image-processing methods for the quantitative assessment of airway hyperresponsiveness from high-resolution CT images.
Development and testing of image-processing methods for the quantitative assessment of airway hyperresponsiveness from high-resolution CT images.
复制标题
开发和测试图像处理方法，用于根据高分辨率 CT 图像定量评估气道高反应性。
DOI：
10.1097/00004728-199711000-00017
复制
发表时间：
1997
影响因子：
1.3
通讯作者：
Aberle,DR
中科院分区：
文献类型：
--
作者：
McNitt-Gray,MF;Goldin,JG;Johnson,TD;Tashkin,DP;Aberle,DR
目的：我们的目标是制定一个协议和图像处理方法，以定量支气管和肺衰减的变化与螺旋高分辨率CT（HRCT）成像的患者。方法：人类受试者进行了螺旋HRCT在两个暂停屏气条件下，功能残气量和残气量，在基线和以下乙酰甲胆碱诱导的支气管激发。使用半自动轮廓绘制程序从不同生理序列中定义解剖学上类似的支气管和轴向肺切片，从中进行面积、形状和衰减的自动测量。由于轮廓绘制的灰度阈值直接影响解剖结构的测量面积，因此进行了两种类型的评价研究。这些包括在体内测量使用基线参数的人类受试者作为标准的参考和体外测量的CT幻影设计，以模拟空气软组织接口的bronchi.Results：幻影测试表明，孔的实际和测量面积之间的最小差异发生在一个阈值为-500 HU。最小直径的孔对阈值的变化最敏感。然而，虽然模拟和人类支气管的绝对面积测量值与阈值水平不同，基线和支气管激发序列之间的气道面积的百分比变化是相对稳定的，在任何给定的threshold.Conclusion：这些图像处理工具提供了可重复的测量面积以及肺结构的衰减特性，并可能提供洞察到实际使用的功能成像在评估条件下的气流阻塞。
Purpose:Our goal was to develop a protocol and image-processing methods to quantitate both bronchial and lung attenuation changes in patients imaged with helical high-resolution CT (HRCT).Method:Human subjects underwent helical HRCT at two suspended breath-hold conditions, functional residual capacity and residual volume, at baseline and following methacholine-induced bronchoprovocation. A semiautomated contouring program was used to define anatomically like bronchi and axial lung sections from the different physiologic sequences, from which automated measurements of area, shape, and attenuation were made. Because the gray level threshold for contouring directly affects the measured area of an anatomic strucutre, two types of evaluation studies were performed. These included in vivo measurements using baseline parameters of human subjects as the standard of reference and in vitro measurements of a CT phantom designed to simulate the air-soft tissue interfaces of bronchi.Results:Phantom tests showed that the minimum difference between actual and measured areas of holes occurred at a threshold of-500 HU. The smallest diameter holes were most sensitive to changes in threshold value. However, although absolute area measurements of both simulated and human bronchi varied with threshold level, the percent changes in airway areas between baseline and bronchoprovocation sequences were relatively stable at any given threshold.Conclusion:These image-processing tools provide reproducible measurements of area as well as attenuation characteristics of pulmonary structures and may offer insights into the practical use of functional imaging in evaluating conditions of airflow obstruction.