Using optically-pumped magnetometers to measure magnetoencephalographic signals in the human cerebellum
Using optically-pumped magnetometers to measure magnetoencephalographic signals in the human cerebellum
复制标题
使用光泵磁力计测量人类小脑中的脑磁信号
DOI：
10.1101/425447
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lin C
中科院分区：
文献类型：
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作者：
Lin C
关键点传统的低温脑磁图（MEG）在小脑功能研究中的应用受到很大限制，因为典型的低温传感器阵列远离小脑，记录时不允许自然运动。这种可以在运动时戴在头上的装置为非侵入性地成像小脑电生理活动提供了机会。信号引起的喷气刺激的眼睛。我们证明了强大的反应在小脑。OPM铺平了道路，研究人类小脑的神经生理学。AbstractWe测试的可行性，光泵磁力计为基础的脑磁图（OP‐MEG）系统测量人类小脑活动。据我们所知，这是第一个研究调查人类小脑电生理学使用光泵磁力计。作为原理的证明，我们使用对眼球的吹气刺激来引起小脑活动，这在非人类模型中得到了很好的表征。在三个主题，我们观察到一个诱发成分在约。刺激后50 ms，然后是第二个分量，刺激后85-115 ms。源反转定位在小脑的两个组件，而控制实验排除其他地方的潜在来源。我们还通过时频分解评估了诱发的振荡，并确定了枕叶（在我们的范例中预期活跃的区域）和颈部肌肉中的其他来源。这两种情况都不会对50-115 ms的刺激诱发反应产生影响。我们的结论是，OP-MEG技术提供了一个有前途的方式来推进人类小脑的信息处理机制的理解。
Key pointsThe application of conventional cryogenic magnetoencephalography (MEG) to the study of cerebellar functions is highly limited because typical cryogenic sensor arrays are far away from the cerebellum and naturalistic movement is not allowed in the recording.A new generation of MEG using optically pumped magnetometers (OPMs) that can be worn on the head during movement has opened up an opportunity to image the cerebellar electrophysiological activity non‐invasively.We use OPMs to record human cerebellar MEG signals elicited by air‐puff stimulation to the eye.We demonstrate robust responses in the cerebellum.OPMs pave the way for studying the neurophysiology of the human cerebellum.AbstractWe test the feasibility of an optically pumped magnetometer‐based magnetoencephalographic (OP‐MEG) system for the measurement of human cerebellar activity. This is to our knowledge the first study investigating the human cerebellar electrophysiology using optically pumped magnetometers. As a proof of principle, we use an air‐puff stimulus to the eyeball in order to elicit cerebellar activity that is well characterized in non‐human models. In three subjects, we observe an evoked component at approx. 50 ms post‐stimulus, followed by a second component at approx. 85–115 ms post‐stimulus. Source inversion localizes both components in the cerebellum, while control experiments exclude potential sources elsewhere. We also assess the induced oscillations, with time‐frequency decompositions, and identify additional sources in the occipital lobe, a region expected to be active in our paradigm, and in the neck muscles. Neither of these contributes to the stimulus‐evoked responses at 50–115 ms. We conclude that OP‐MEG technology offers a promising way to advance the understanding of the information processing mechanisms in the human cerebellum.