FUNCTIONAL AND ANATOMICAL CORRELATION OF AFFERENT RESPONSES FROM ISOLATED SEMICIRCULAR CANAL
FUNCTIONAL AND ANATOMICAL CORRELATION OF AFFERENT RESPONSES FROM ISOLATED SEMICIRCULAR CANAL
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DOI：
10.1038/251225a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
HONRUBIA, V
中科院分区：
文献类型：
--
作者：
OLEARY, DP;DUNN, RF;HONRUBIA, V
半规管被认为是经典的角度头部运动在动物导航的传感器，然而，管道的形态和神经支配的转导和编码特定的头部轨迹的功能意义尚不清楚。Groenet al.to使用了支配孤立的板鳃类动物嵴的单个传入纤维的神经反应来确定过阻尼摆方程的线性系统系数，该方程被认为直接反映壶腹中的杯状内淋巴液的运动动力学1。对其他制剂的类似研究揭示了与单摆模型不同的某些神经反应特征，这些差异被不同地归因于毛细胞生理学和传入或传出神经支配特性的差异，其影响叠加在基本流体摆动力学上2 -4。但是除了这些基于细胞影响的假设之外，受体的拓扑组织可能导致来自嵴内不同解剖区域的特定传入反应特征。作为后者的证据，我们报告了不同类型的传入反应，可以通过明显不同的线性系统方程描述，这些反应与神经支配吉他鱼（Rhinobatos productus）脊特定区域的单独束的位置相关（图1）。
THE semicircular canal is considered classically to be a sensor of angular head motion during animal navigation; however, the functional significance of the canal's morphology and innervation for transduction and encoding of specific head trajectories is unclear. Neural responses from single afferent fibres innervating the crista of isolated elasmobranch labyrinths were used by Groenet al.to determine linear system coefficients of an overdamped pendulum equation, considered to reflect directly the dynamics of the motion of the cupula–endolymphatic fluid in the ampulla1. Similar studies on other preparations revealed certain neural response characteristics that were at variance with simple pendulum models, and these differences were ascribed variously to differences in hair cell physiology and afferent or efferent innervation properties, whose effects were superimposed on the fundamental fluid pendulum dynamics2–4. But in addition to these hypotheses based on cellular influences, the topological organisation of the receptor could result in specific afferent response characteristics deriving from different anatomical regions within the crista. As evidence for the latter, we report diverse classes of afferent responses, describable by distinctly different linear system equations, that are correlated with the position of separate bundles innervating specific areas of the crista of the guitarfish,Rhinobatos productus(Fig. 1).