High prevalence of exocrine pancreatic insufficiency in diabetes mellitus - A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients
High prevalence of exocrine pancreatic insufficiency in diabetes mellitus - A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients
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DOI：
10.1159/000073655
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发表时间：
2003-01-01
期刊：
影响因子：
3.6
通讯作者：
Kloer, HU
中科院分区：
文献类型：
--
作者：
Hardt, PD;Hauenschild, A;Kloer, HU
背景：已有大量关于糖尿病胰腺外分泌功能障碍的直接或间接功能试验的报道。粪便弹性蛋白酶1浓度（FEC）的测量已被用作外分泌胰腺疾病的筛选工具，在不同的患者群体中，外分泌功能障碍的发病率很高。在这项研究中，我们有机会研究了1，000多名糖尿病患者，以证实最近在较小人群中的观察结果。方法：采用酶联免疫吸附试验（ELISA）检测323例1型糖尿病患者和697例2型糖尿病患者的前向血糖（FEC）.不包括有酗酒、胃肠道手术、癌症或炎性疾病史的受试者。使用标准病例报告表记录糖尿病史和临床数据。调查结果：研究了1，021例患者（334例女性，687例男性;平均年龄50岁;平均糖尿病病程11年;平均糖尿病发病年龄39岁）。59.3%的患者FEC正常（>200 mug/g），
Background: There have been numerous reports on pancreatic exocrine dysfunction in diabetes mellitus using either direct or indirect function tests. The measurement of fecal elastase 1 concentrations (FEC) has been used as a screening tool for exocrine pancreatic disease in different patient groups indicating a high prevalence of exocrine dysfunction in diabetic populations. In this study we had the opportunity to study more than 1,000 diabetic patients to confirm recent observations in smaller populations. Methods: FEC were measured by ELISA in 323 patients with type 1 and 697 type 2 diabetes mellitus. Subjects with a history of alcohol abuse, gastrointestinal surgery, cancer or inflammatory diseases were not included. Diabetes history and clinical data were recorded using a standard case report form. Findings: 1,021 patients (334 female, 687 male; mean age 50 years; mean diabetes duration 11 years; mean age at onset of diabetes 39 years) were studied. FEC was normal (>200 mug/g) in 59.3% and severely reduced (