Prevalence of age-related maculopathy in older Europeans - The European Eye Study (EUREYE)
Prevalence of age-related maculopathy in older Europeans - The European Eye Study (EUREYE)
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DOI：
10.1001/archopht.124.4.529
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发表时间：
2006-04-01
影响因子：
--
通讯作者：
Fletcher, AE
中科院分区：
文献类型：
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作者：
Augood, CA;Vingerling, JR;Fletcher, AE
目的：为了估计年龄相关性黄斑病变的患病率在老年人群从7个欧洲countries.Methods：随机抽样的人65岁及以上被邀请到眼科检查中心在7个欧洲国家（挪威，爱沙尼亚，英国，法国，意大利，希腊和西班牙）。每只眼睛的眼底图像在一个阅读中心进行分级。患病率计算阶段的年龄相关性黄斑病变与95%的置信区间（CI）估计聚类data.Results：5040名参与者（45%的响应率），4753（2128名男性和2625名女性）有分级眼底图像。患病率为0级，47.59%（95%CI，43.53%-51.65%）; 1级，36.48%（95%CI，32.66%-40.30%）; 2级，10.14%（95% CI，8.92%-11.37%）; 3级，2.46%（95% CI，1.79%~ 3.13%）;和4级（年龄相关性黄斑变性[AMD]）3.32%（95% CI，2.52%~ 4.13%），仅大玻璃疣（≥ 125 μ m）15.41%（95% CI，13.61%~ 17.21%）。地图状萎缩性AMD的患病率为1.2%（95% CI，0.8%-1.7%），新生血管性AMD的患病率为2.3%（95% CI，1.7%-2.9%）。双侧AMD的患病率为1.4%（95%CI，1.0%-1.8%）。结论：欧洲眼科研究（EUREYE）中年龄相关性黄斑病变的视网膜特异性患病率与西方人群中其他基于人群的研究相似。
Objective: To estimate the prevalence of age-related maculopathy in an older population from 7 European countries.Methods: Randomly sampled people 65 years and older were invited to an eye examination in centers across 7 European countries (Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain). Fundus images of each eye were graded at a single reading center. Prevalence rates were calculated for stage of age-related maculopathy with 95% confidence intervals (CIs) estimated for clustered data.Results: Of 5040 participants (45% response rate), 4753 (2128 men and 2625 women) had gradable fundus images. The prevalences were grade 0, 47.59% (95% CI, 43.53%-51.65%); grade 1,36.48%( 95% CI, 32.66%-40.30%); grade 2,10.14% (95% CI, 8.92% to 11.37%); grade 3,2.46% (95% CI, 1.79%-3.13%); and grade 4 (age-related macular degeneration [AMD]), 3.32% (95% CI, 2.52%-4.13%) and large drusen only (>= 125 mu m), 15.41% (95% CI, 13.61%-17.21%). The prevalence of geographic atrophic AMD was 1.2% (95% CI, 0.8%-1.7%) and of neovascular AMD, 2.3% (95% CI, 1.7%-2.9%). The prevalence of bilateral AMD was 1.4% (95% CI, 1.0%-1.8%).Conclusion: Age-specific prevalences of age-related maculopathy in the European Eye Study (EUREYE) are similar to other population-based studies in Western populations.