Dose-response effects of atropine on thermal stimulus-response relationships in asthma.
Dose-response effects of atropine on thermal stimulus-response relationships in asthma.
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阿托品对哮喘热刺激反应关系的剂量反应作用。
DOI：
10.1152/jappl.1982.53.6.1576
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
McFaddenJr,ER
中科院分区：
文献类型：
--
作者：
Griffin,MP;Fung,KF;IngramJr,RH;McFaddenJr,ER
为了确定胆碱能阻断如何改变对热刺激的刺激-反应关系，我们让 7 名哮喘患者在用剂量为 0.25、0.5、1.0、3.0 和 6.0 mg 的盐水和阿托品气雾剂预处理后，对低于冰点的空气 (-10.6 +/- 1.9 摄氏度) 进行增加水平的真二氧化碳过度通气。使用安慰剂和单剂量药物在不同的 5 天进行测试。在对照实验中，增加通气量以刺激-反应方式导致 1 秒用力呼气量逐渐减少。任何安慰剂研究之间都没有显着差异。阿托品预处理并没有消除任何剂量的气道冷却的阻塞反应，而是将刺激-反应曲线向右移动，以便可以通过增加刺激来克服毒蕈碱阻断的影响。 0.25 毫克或 6 毫克阿托品观察到的结果没有显着差异。这些数据表明，胆碱能机制在运动诱发的支气管痉挛中最多只发挥很小的作用，并为文献中关于这种情况下抗毒蕈碱药物的不同发现提供了统一的解释。
To determine how cholinergic blockade modifies the stimulus-response relationships to thermal provocations, we had seven asthmatics perform increasing levels of eucapnic hyperventilation of subfreezing air (-10.6 +/- 1.9 degrees C) after pretreatment with aerosols of saline and atropine in doses of 0.25, 0.5, 1.0, 3.0, and 6.0 mg. Testing was performed on 5 separate days with both placebo and a single dose of drug. In control experiments, increasing ventilation produced a progressive decrease in the 1-s forced expiratory volume in a stimulus-response fashion. There were no significant differences between any placebo study. Atropine pretreatment did not abolish the obstructive response to airway cooling at any dose but, rather, shifted the stimulus-response curve to the right, so that the effects of muscarinic blockade could be overcome by increasing the stimulus. There were no significant differences between the results observed with 0.25 or 6 mg of atropine. These data demonstrate that cholinergic mechanisms play, at best, a very minor role in exercise-induced bronchospasm and offer a unifying explanation for the disparate findings in the literature regarding antimuscarinic agents in this condition.