INTRA-CRANICAL SELF-ADMINISTRATION OF MORPHINE INTO THE VENTRAL TEGMENTAL AREA IN RATS
INTRA-CRANICAL SELF-ADMINISTRATION OF MORPHINE INTO THE VENTRAL TEGMENTAL AREA IN RATS
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DOI：
10.1016/0024-3205(81)90148-x
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发表时间：
1981-01-01
期刊：
影响因子：
6.1
通讯作者：
WISE, RA
中科院分区：
文献类型：
--
作者：
BOZARTH, MA;WISE, RA
使用自我给药程序研究了直接注射到腹侧被盖区的吗啡的有益特性。实验中，幼鼠表现出快速获得杠杆按压反应，产生 100 ng 硫酸吗啡溶液输注。反应率相对稳定，并且明显超过被动接受相同输注模式（即轭控制程序）的大鼠的杠杆按下率。纳洛酮有效地阻断了颅内自我给药，表明这种行为是通过阿片受体介导的，而不是机械创伤或渗透压或 pH 值变化的结果。
The rewarding properties of morphine injected directly into the ventral tegmental area were investigated using a self-administration procedure. Experimentally naive rats demonstrated rapid acquisition of a lever-pressing response which produced a 100 ng infusion of morphine sulfate solution. Response rates were relatively stable and markedly exceeded lever-press rates of rats passively receiving the same pattern of infusions (i.e., yoked control procedure). Intracranial self-administration was effectively blocked by naloxone suggesting that this behavior is mediated through opiate receptors and is not the consequence of mechanical trauma, or changes in osmolarity or pH.