Quantitative sensory test for primary restless legs syndrome/Willise-Ekbom disease using the current perception threshold test
Quantitative sensory test for primary restless legs syndrome/Willise-Ekbom disease using the current perception threshold test
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DOI：
10.1016/j.sleep.2016.03.003
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发表时间：
2017-02-01
期刊：
影响因子：
4.8
通讯作者：
Motamedi, Gholam K.
中科院分区：
文献类型：
--
作者：
Cho, Yong Won;Kang, Min-Sung;Motamedi, Gholam K.
背景：不宁腿综合征/Willise-Ekbom病（RLS/WED）是一种感觉运动神经系统疾病，尤其在夜间加重。本研究的目的是探讨昼夜感觉功能障碍在原发性RLS/WED使用电流感知阈值（CPT）测试，与健康controls.Methods：30个原发性RLS/WED的受试者和30名健康对照者。评估所有受试者的RLS/WED和睡眠问题的严重程度。通过神经系统检查和神经传导检查排除周围多发性神经病。我们使用Neurometer（R）系统进行CPT测试，并应用三种不同的参数（2000 Hz、250 Hz和5 Hz）来刺激两个大脚趾。CPT测试进行了两次，一次在无症状的白天期间，再次在晚上，当患者symptomatic.Results：RLS/WED组和对照组的平均年龄分别为50.5 +/- 11.7（22; 73.3%的女性），和46.3 +/- 11.4（24; 80.0%的女性），分别。平均国际RLS/WED研究组严重程度量表评分为28.6 +/- 4.25。RLS/WED患者与对照组在白天的电流感知阈值无显著差异。然而，RLS/WED患者在晚上的所有三种刺激方案的平均CPT测量值较低（2000 Hz：393.2 +/- 93.7 vs 430.8 +/- 79.6，250 Hz：172.0 +/- 48.4 vs 198.5 +/- 38.2，5 Hz：98.0 +/- 34.1 vs 124.6 +/- 31.3），而健康对照组无差异。RLS患者在晚上表现出较低的CPT。RLS/WED患者痛觉过敏的昼夜变化表明中枢（昼夜）感觉处理障碍，而不是外周障碍。(C)2016爱思唯尔B. V.保留所有权利。
Background: Restless legs syndrome/Willise-Ekbom disease (RLS/WED) is a sensorimotor neurological disorder, and it is especially aggravated at night. The purpose of this study was to investigate the diurnal sensory dysfunction in primary RLS/WED using the current perception threshold (CPT) test, compared to healthy controls.Methods: Thirty primary RLS/WED subjects and 30 healthy controls were enrolled. The severity of RLS/WED and sleep problems were evaluated in all subjects. Peripheral polyneuropathy was excluded through neurological examination and nerve conduction study. We used the Neurometer (R) system for the CPT test and applied three different parameters (2000 Hz, 250 Hz, and 5 Hz), to stimulate both big toes. The CPT test was performed twice, once during the asymptomatic daytime period and again in the evening, when the patients were symptomatic.Results: The mean ages of the RLS/WED group and controls were 50.5 +/- 11.7 (22; 73.3% female), and 46.3 +/- 11.4 (24; 80.0% female), respectively. The mean international RLS/WED study group severity scale score was 28.6 +/- 4.25. There was no significant difference in the current perception thresholds between the RLS/WED patients and controls in daytime. However, the RLS/WED patients had lower mean CPT measurements for all three stimulation protocols in the evening (2000 Hz: 393.2 +/- 93.7 vs 430.8 +/- 79.6, 250 Hz: 172.0 +/- 48.4 vs 198.5 +/- 38.2, and 5 Hz: 98.0 +/- 34.1 vs 124.6 +/- 31.3), while the healthy controls showed no difference.Conclusions: RLS patients showed a lower CPT in the evening. The diurnal variation of hyperalgesia in RLS/WED patients indicates a central (circadian) sensory processing disturbance rather than a peripheral disturbance. (C) 2016 Elsevier B.V. All rights reserved.