Pavlovian second-order conditioned analgesia.
Pavlovian second-order conditioned analgesia.
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巴甫洛夫二阶条件镇痛。
DOI：
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发表时间：
1986
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影响因子：
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通讯作者：
R. Ross
中科院分区：
文献类型：
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作者：
R. Ross
三个实验与大鼠受试者评估条件性镇痛在巴甫洛夫二阶条件反射程序通过使用抑制反应热刺激作为疼痛敏感性的指数。在实验1中，接受二阶条件反射的大鼠在二阶条件刺激（CS）的存在下进行疼痛敏感性测试时，比接受适当控制程序的大鼠表现出更长的反应潜伏期。实验2发现，灭绝的一阶CS没有建立二级条件镇痛的影响。实验三考察了吗啡和电击非条件刺激（US）的后二阶条件反射效应。接受成对吗啡休克介绍的大鼠表现出显着较短的反应延迟在热板测试的疼痛敏感性的存在下，二阶CS比组的大鼠接受各种控制程序;二阶镇痛衰减。这些数据扩展关联帐户的条件镇痛二阶条件的情况下，并讨论了调解的第一和第二阶镇痛的CS和代表或预期的美国，这可能直接激活内源性疼痛抑制系统之间的关联。
Three experiments with rat subjects assessed conditioned analgesia in a Pavlovian second-order conditioning procedure by using inhibition of responding to thermal stimulation as an index of pain sensitivity. In Experiment 1, rats receiving second-order conditioning showed longer response latencies during a test of pain sensitivity in the presence of the second-order conditioned stimulus (CS) than rats receiving appropriate control procedures. Experiment 2 found that extinction of the first-order CS had no effect on established second-order conditioned analgesia. Experiment 3 evaluated the effects of post second-order conditioning pairings of morphine and the shock unconditioned stimulus (US). Rats receiving paired morphine-shock presentations showed significantly shorter response latencies during a hot-plate test of pain sensitivity in the presence of the second-order CS than did groups of rats receiving various control procedures; second-order analgesia was attenuated. These data extend the associative account of conditioned analgesia to second-order conditioning situations and are discussed in terms of the mediation of both first- and second-order analgesia by an association between the CS and a representation or expectancy of the US, which may directly activate endogenous pain inhibition systems.