Long Non-Coding RNAs Embedded in the Rb and p53 Pathways.
Long Non-Coding RNAs Embedded in the Rb and p53 Pathways.
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嵌入在RB和p53途径中的长非编码RNA。
DOI：
10.3390/cancers5041655
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发表时间：
2013-12-04
期刊：
影响因子：
5.2
通讯作者：
Lal A
中科院分区：
文献类型：
--
作者：
Subramanian M;Jones MF;Lal A
长链非编码rna （long non-coding RNAs, lncRNAs）作为一类新型的基因调控因子，近年来受到了广泛的关注。虽然有少数lncrna通过转录调控、mRNA剪接和翻译等多种机制调控基因表达，但绝大多数lncrna的生理功能和作用机制尚不清楚。细胞系和肿瘤样本的分析研究表明lncrna在癌症中的潜在作用。事实上，不同的lncrna已被证明嵌入在p53和Rb网络中，这是控制细胞周期进展和存活的两种主要肿瘤抑制途径。考虑到Rb和p53的失活是人类癌症的一个标志，在这篇综述中，我们讨论了lncrna在Rb和p53信号通路中的功能的最新证据。
In recent years, long non-coding RNAs (lncRNAs) have gained significant attention as a novel class of gene regulators. Although a small number of lncRNAs have been shown to regulate gene expression through diverse mechanisms including transcriptional regulation, mRNA splicing and translation, the physiological function and mechanism of action of the vast majority are not known. Profiling studies in cell lines and tumor samples have suggested a potential role of lncRNAs in cancer. Indeed, distinct lncRNAs have been shown to be embedded in the p53 and Rb networks, two of the major tumor suppressor pathways that control cell cycle progression and survival. Given the fact that inactivation of Rb and p53 is a hallmark of human cancer, in this review we discuss recent evidence on the function of lncRNAs in the Rb and p53 signaling pathways.