Epsins' novel role in cancer cell invasion.
Epsins' novel role in cancer cell invasion.
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DOI：
10.4161/cib.4.1.14129
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Aguilar, R Claudio
中科院分区：
文献类型：
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作者：
Coon, Brian G;Direnzo, Daniel M;Aguilar, R Claudio
已发现内吞衔接子的epsin家族在癌症中上调;然而，这些发现与这种病理状况的相关性尚不清楚。我们最近已经证明，epsin是细胞迁移所必需的。事实上，epsin过度表达促进癌细胞侵袭。此外，与我们先前的发现一致，我们还观察到epsins的过表达导致上皮细胞迁移超出集落边界。此外，我们的研究结果表明，epsin-3是增强细胞迁移和侵袭的最有效的paraffin。有趣的是，epsin-3表达并不广泛，但高度局限于迁移性角质形成细胞和侵袭性癌。在进一步的研究中，我们还鉴定了epsin-3在胰腺癌细胞中表达。这些发现表明，EPN 3基因的上调与侵袭性、侵袭性癌症特异性相关。我们预测，这些内吞机制和机制之间的联系，参与肿瘤传播的调查将有助于新的抗转移和抗癌策略的发展。
The epsin family of endocytic adaptors has been found to be upregulated in cancer; however the relevance of these findings to this pathological condition is unclear. We have recently demonstrated that epsins are required for cell migration. In fact, epsin overexpression promotes cancer cell invasion. Further, and in agreement with our previous findings, we also observed that overexpression of epsins led to epithelial cell migration beyond colony boundaries. Additionally, our results show that epsin-3 is the most potent paralog enhancing cell migration and invasion. Interestingly, epsin-3 expression is not widespread but highly restricted to migratory keratinocytes and aggressive carcinomas. Upon further investigation, we also identified epsin-3 as being expressed in pancreatic cancer cells. These findings suggest that upregulation of the EPN3 gene is specifically associated with invasive, aggressive cancers. We predict that investigation of these links between the endocytic machinery and mechanisms involved in tumor dissemination will contribute to the development of novel anti-metastatic and anti-cancer strategies.