Plasma thiobarbituric acid-reactive substance levels in subclinical hypothyroidism
Plasma thiobarbituric acid-reactive substance levels in subclinical hypothyroidism
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DOI：
10.1159/000107747
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Yesil, Sena
中科院分区：
文献类型：
--
作者：
Kebapcilar, Levent;Akinci, Baris;Yesil, Sena
目的：本研究的目的是确定硫代巴比妥酸反应物质（TBARS）水平在亚临床甲状腺功能减退症，并检查左甲状腺素替代对TBARS水平的影响。对象和方法：28例亚临床甲状腺功能减退症女性患者和24例健康对照者入选本研究。对亚临床甲减患者基线时和通过左旋甲状腺素达到甲状腺功能正常状态后的血浆TBARS、血脂和高敏C反应蛋白（CRP）水平进行评估。结果如下：在亚临床甲状腺功能减退状态和经左旋甲状腺素替代治疗恢复甲状腺功能后，患者的TBARS水平与对照组相似。左甲状腺素治疗后TBARS水平下降，但未达到统计学显著性。TBARS、血脂和CRP水平之间无显著相关性。亚临床甲状腺功能减退症患者的血清CRP水平（4.28 +/- 0.9 mg/l）高于对照组（1.95 +/- 0.34 mg/l），差异具有统计学意义（p = 0.03）。在达到甲状腺功能正常状态后，亚临床甲状腺功能减退症患者的CRP水平从4.28 +/- 0.9 mg/l显著降低至2.32 +/- 0.6 mg/l（p = 0.006）。结论：我们的研究结果表明，无论是在亚临床甲状腺功能减退状态或甲状腺功能正常状态后，血浆TBARS水平没有显着变化。亚临床甲减患者血清CRP水平高于对照组。甲状腺状态正常化似乎可以有效降低亚临床甲状腺功能减退症患者的血清CRP水平，而与TBARS活性无任何相关性。版权所有（C）2007 S. Karger AG，巴塞尔。
Objective: The purpose of this study was to determine thiobarbituric acid-reactive substance (TBARS) levels in subclinical hypothyroidism and to examine the effect of levothyroxine replacement on TBARS levels. Subjects and Methods: A cohort of 28 female patients with subclinical hypothyroidism and 24 healthy controls were enrolled in this study. The levels of plasma TBARS, serum lipids, and high-sensitive C-reactive protein (CRP) in patients with subclinical hypothyroidism at baseline and after achieving euthyroid state by levothyroxine were assessed. Results: TBARS levels of the patients were similar to those of the control group in the subclinical hypothyroid state and after restoration of euthyroidism by levothyroxine replacement. TBARS levels decreased after levothyroxine treatment, but did not reach statistical significance. There was no significant correlation between TBARS, lipid and CRP levels. Serum CRP levels were higher in subclinical hypothyroidism (4.28 +/- 0.9 mg/l) than in the control group (1.95 +/- 0.34 mg/l) and the difference was statistically significant (p = 0.03). After achieving euthyroid state, CRP levels decreased significantly in patients with subclinical hypothyroidism from 4.28 +/- 0.9 to 2.32 +/- 0.6 mg/l (p = 0.006). Conclusion: Our findings suggest that there is no significant alteration of plasma TBARS levels neither in subclinical hypothyroid state nor after achieving euthyroid state. Serum CRP level is higher in patients with subclinical hypothyroidism than in the control group. Normalization of thyroid state seems to effectively reduce serum CRP levels in subclinical hypothyroidism without any correlation with TBARS activity. Copyright (C) 2007 S. Karger AG, Basel.