Causal role of prefrontal cortex in the threshold for access to consciousness
Causal role of prefrontal cortex in the threshold for access to consciousness
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DOI：
10.1093/brain/awp111
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发表时间：
2009-09-01
期刊：
影响因子：
14.5
通讯作者：
Slachevsky, A.
中科院分区：
文献类型：
--
作者：
Del Cul, A.;Dehaene, S.;Slachevsky, A.
什么神经机制支持我们对短暂呈现的刺激的意识知觉？一些意识获取理论假设涉及前额皮质（PFC）的自上而下的放大回路起关键作用。为了验证这个问题，我们测量了局灶性前额叶病变患者的视觉后向掩蔽阈值，在控制假定的注意力缺陷的同时，使用客观和主观测量方法。在所有的时间或空间注意提示条件下，患者进入意识的阈值都有系统地改变，尤其是在左前pfc病变后。这种缺陷对主观报告的影响大于客观表现，而以主观可见性为条件的客观表现基本上是正常的。我们得出结论，PFC对隐藏刺激的有意识视觉感知有因果关系，并概述了客观和主观决策的双路径信号检测理论。
What neural mechanisms support our conscious perception of briefly presented stimuli Some theories of conscious access postulate a key role of topdown amplification loops involving prefrontal cortex (PFC). To test this issue, we measured the visual backward masking threshold in patients with focal prefrontal lesions, using both objective and subjective measures while controlling for putative attention deficits. In all conditions of temporal or spatial attention cueing, the threshold for access to consciousness was systematically shifted in patients, particular after a lesion of the left anterior PFC. The deficit affected subjective reports more than objective performance, and objective performance conditioned on subjective visibility was essentially normal. We conclude that PFC makes a causal contribution to conscious visual perception of masked stimuli, and outline a dual-route signal detection theory of objective and subjective decision making.