Review of Non-coding RNAs and the epigenetic regulation of gene expression: A book edited by Kevin Morris
Review of Non-coding RNAs and the epigenetic regulation of gene expression: A book edited by Kevin Morris
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DOI：
10.4161/epi.20170
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发表时间：
2012-06-01
期刊：
影响因子：
3.7
通讯作者：
Blignaut M
中科院分区：
文献类型：
--
作者：
Blignaut M
在过去的二十年里，测序和检测技术的进步，尤其是人类基因组计划带来的数据爆炸，已经将以前被认为是相对简单的遗传景观转变为一种新的图景，即所谓的基因组“暗物质”已经从不那么时髦的蛋白质编码基因中偷走了聚光灯。简化的分子生物学中心法则，即基因通过信使RNA（mRNA）编码蛋白质，仍然是遗传学的核心，但现在被以前称为“垃圾”DNA的基因组区域陷入了更复杂的调控网络。Caister Academic Press出版的Non-coding RNAs and epigenetic regulation of gene expression等书籍成为帮助我们了解快速RNA研究领域现状的重要指南，该领域刚刚开始揭示非编码RNA（ncRNAs）在基因表达调控中的作用。
Advances in sequencing and detection technology over the past two decades, highlighted by the data explosion brought about by the human genome project, have transformed what was previously assumed to be a relatively simple genetic landscape into a new picture where the so-called “dark matter” of the genome has stolen the spotlight from the not so hip protein-coding genes. The simplified central dogma of molecular biology, in which a gene encodes for a protein via a messenger RNA (mRNA), is still at the core of genetics but is now caught in a much more complex web of regulation by the genomic region previously known as “junk” DNA. Books such as Non-coding RNAs and epigenetic regulation of gene expression, published by Caister Academic Press, become essential guidelines to help us understand the current status of the very fast paced field of RNA research, which has only just started to uncover the roles of non-coding RNAs (ncRNAs) in the regulation of gene expression.