A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults.
A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults.
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DOI：
10.1186/s40798-015-0032-x
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Murphy MH
中科院分区：
文献类型：
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作者：
Brown WM;Davison GW;McClean CM;Murphy MH
心血管疾病（CVD）是全球死亡的主要原因。虽然有规律的运动可以降低发病率，但单次运动对特定心血管疾病危险因素的健康益处尚不清楚。本综述的主要目的是考虑运动对未经训练的成年人免疫（中性粒细胞计数）和炎症（白细胞介素-6 [IL-6]， c反应蛋白[CRP]）标志物的短暂影响。检索了MEDLINE、EMBASE、CINAHL、Sports Discus和Cochrane在1946年1月至2013年5月间发表的相关研究。随机对照或交叉研究在未受过训练但其他方面健康的参与者中测量了这些参数中的任何一个，在运动后48小时内，持续时间少于1小时。10项研究符合纳入标准。结果表明，单次中等至高强度的有氧或阻力运动可促进IL-6（145%）和中性粒细胞计数（51%）的增加。虽然运动模式、强度和模式等变量也会影响反应，但似乎30-60分钟的中等到高强度运动是引起这种变化的必要条件。在纳入的研究中，CRP的急性反应是模棱两可的。尽管对CRP的反应是不一致的，但在未经训练的成年人中，单次运动可以增加循环IL-6和中性粒细胞计数的活性。单次锻炼的这些免疫和炎症反应可能与一系列健康益处有关。
Cardiovascular disease (CVD) is the leading cause of global mortality. Although the incidence may be reduced with regular exercise, the health benefits of a single bout of exercise on selected CVD risk factors are not well understood. The primary objective of this review is to consider the transient effects of exercise on immune (neutrophil count) and inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]) markers in untrained adults. MEDLINE, EMBASE, CINAHL, Sports Discus and Cochrane were searched for relevant studies published from January 1946 to May 2013. Randomised controlled or crossover studies which measured any of these parameters in untrained but otherwise healthy participants in the 48 h following about of exercise, less than 1 h in duration were included. Ten studies met the inclusion criteria. The results indicate a single bout of aerobic or resistance exercise of moderate to high intensity promotes an increase in IL-6 (145 %) and neutrophil counts (51 %). It appears that 30–60 min of moderate to high intensity exercise is necessary to elicit such changes although variables such as the mode, intensity and pattern of exercise also affect the response. The acute response of CRP within the included studies is equivocal. Although responses to CRP are inconsistent, a single bout of exercise can increase the activity of both circulating IL-6 and neutrophil counts in untrained adults. These immune and inflammatory responses to a single bout of exercise may be linked to a range of health benefits.