Carbamazepine and fatal eosinophilic myocarditis.
Carbamazepine and fatal eosinophilic myocarditis.
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卡马西平和致命的嗜酸细胞性心肌炎。
DOI：
10.1056/nejm199703203361216
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
S. Sood
中科院分区：
文献类型：
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作者：
M. Salzman;E. Valderrama;S. Sood
致编辑：我们描述了一名患有注意力缺陷多动障碍的 13 岁男孩，他出现发烧、皮疹、结膜炎、肝炎、心肌炎和嗜酸性粒细胞增多，并在开始卡马西平治疗后约两个月死亡。一篇关于急性心肌病儿童心肺复苏期间经静脉右心室起搏的文章报道了该患者的心肺复苏 (CPR)。1 该儿童是精神病科的住院患者。在对哌醋甲酯和可乐定没有反应后，他因攻击性和冲动行为而开始接受卡马西平治疗（100 毫克，每天两次）。卡马嗪剂量逐渐增加至800 mg。 。 。
To the Editor: We describe a 13-year-old boy with attention deficit–hyperactivity disorder in whom fever, rash, conjunctivitis, hepatitis, myocarditis, and eosinophilia developed and who died about two months after the start of carbamazepine therapy. The cardiopulmonary resuscitation (CPR) of this patient was reported in an article on transvenous right ventricular pacing during CPR in children with acute cardiomyopathy.1 The child was an inpatient on a psychiatric unit. His carbamazepine treatment (100 mg twice a day) was initiated for aggressive and impulsive behavior after he did not respond to methylphenidate and clonidine. The carbamaz-epine dose was gradually increased to 800 mg . . .