A characterization of the respiratory pattern of gasping.
A characterization of the respiratory pattern of gasping.
复制标题
喘气呼吸模式的特征。
DOI：
10.1152/jappl.1981.50.5.984
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Knuth,KV
中科院分区：
文献类型：
--
作者：
StJohn,WM;Knuth,KV
本研究的目的是比较喘息与正常呼吸和呼吸暂停的呼吸模式。使用去大脑、小脑切除、迷走神经切断、瘫痪和通气的猫。通过膈神经活动评估的通气模式，通过使用位于脑桥吻端或通过脑桥延髓连接处的冷却热电极可逆地从呼吸正常改变为呼吸暂停或喘气。脑干损伤或适当部位冻结导致不可逆的呼吸暂停或喘气。对膈活动的分析表明，喘气的发生率和上升率远高于呼吸正常或呼吸暂停吸气的发生率和上升率。此外，与平静呼吸或呼吸暂停相比，喘息的频率和强度均不会因高碳酸血症、低碳酸血症或氰化钠刺激颈动脉化学感受器而改变。尽管缺氧导致喘息频率增加，但这种反应是短暂的并且不依赖于颈动脉化学感受器机制。这些结果并没有支持以下概念：位于髓质的共同机制是所有自动通气模式的神经发生的基础。
The purpose of this investigation was to compare the respiratory pattern of gasping with eupnea and apneusis. Decerebrate, cerebellectomized, vagotomized, paralyzed and ventilated cats were used. The ventilatory pattern, assessed by phrenic nerve activity, was reversibly altered from eupnea to apneusis or gasping by use of a cooling-for, thermode positioned inm the rostral pons or through the pontomedullary junction, respectively. Irreversible apneusis or gasping resulted from brain stem lesions or freezing at appropriate loci. Analysis of phrenic activity revealed that the rates of onset and rise of the gasp were much greater than those of the eupneic or apneustic inspiration. Moreover, in contrast to eupnea or apneusis, neither the frequency nor the intensity of gasps was altered by hypercapnia, hypocapnia, or carotid chemoreceptor stimulation by sodium cyanide. Although hypoxia caused an increase in gasping frequency, this response was transient and not dependent on carotid chemoreceptor mechanisms. These results provide no support for the concept that common mechanisms localized in medulla, underlie the neurogenesis of all automatic ventilatory patterns.