Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
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DOI：
10.3390/v12060680
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发表时间：
2020-06-01
期刊：
影响因子：
4.7
通讯作者：
An, Dong-Jun
中科院分区：
文献类型：
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作者：
Choe, SeEun;Park, Gyu-Nam;An, Dong-Jun
非典型猪瘟病毒（APPV），目前被归类为Aspestivirus K，引起仔猪先天性震颤（CT）A-II型。从2019年捕获的2297头韩国野猪中鉴定出18株APPV毒株。系统发育分析的结构蛋白E2和非结构蛋白NS 3和Npro的APPV病毒，包括参考株，分为支I，II和III。进化枝I分为四个亚进化枝;然而，属于四个亚进化枝的菌株略有不同，这取决于树分析、NS 3、E2和Npro基因。最大似然法被分配到韩国野猪APPV株的各种亚支内的三个树：亚支I.1和I.2在E2树，亚支I.1在Npro树，亚支I.1和I.4在NS 3 ML树。总之，APPV在韩国野猪中属于分支I，可能比韩国家猪种群中传播的水平更高。
Atypical porcine pestivirus (APPV), currently classified aspestivirus K, causes congenital tremor (CT) type A-II in piglets. Eighteen APPV strains were identified from 2297 South Korean wild boars captured in 2019. Phylogenetic analysis of the structural protein E2 and nonstructural proteins NS3 and Npro classified the APPV viruses, including reference strains, into Clades I, II and III. Clade I was divided into four subclades; however, the strains belonging to the four subclades differed slightly, depending on the tree analysis, the NS3, E2, and Npro genes. The maximum-likelihood method was assigned to South Korean wild boar APPV strains to various subclades within the three trees: subclades I.1 and I.2 in the E2 tree, subclade I.1 in the Npro tree, and subclades I.1 and I.4 in the NS3 ML tree. In conclusion, APPV among South Korean wild boars belonging to Clade I may be circulating at a higher level than among the South Korean domestic pig populations.