Solid‐phase peptide synthesis of human(Nle‐27)‐oxyntomodulin
Solid‐phase peptide synthesis of human(Nle‐27)‐oxyntomodulin
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人(Nle-27)-泌酸调节素的固相肽合成
DOI：
10.1016/0014-5793(86)80535-x
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发表时间：
1986
期刊：
影响因子：
3.5
通讯作者：
J. Martinez
中科院分区：
文献类型：
--
作者：
M. Audousset;M. Dufour;A. Kervran;C. Jarrousse;B. Castro;D. Bataille;J. Martinez
胃泌酸调节素是从猪肠中分离的肽，其由在其C末端部分通过碱性八肽延伸的整个胰高血糖素序列组成。人序列的类似物（Nle-27）-胃泌酸调节素已通过固相肽合成法合成，通过HPLC纯化并鉴定。其生物活性与天然激素相同。
Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C‐terminal part by a basic octapeptide. The analogue (Nle‐27)‐oxyntomodulin of the human sequence has been synthesized by solid‐phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone.