RADICAL RADIATION-THERAPY WITH 5-FLUOROURACIL INFUSION AND MITOMYCIN-C FOR ESOPHAGEAL SQUAMOUS CARCINOMA
RADICAL RADIATION-THERAPY WITH 5-FLUOROURACIL INFUSION AND MITOMYCIN-C FOR ESOPHAGEAL SQUAMOUS CARCINOMA
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DOI：
10.1016/s0167-8140(85)80085-2
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发表时间：
1985-01-01
影响因子：
5.7
通讯作者：
COOPER, JC
中科院分区：
文献类型：
--
作者：
KEANE, TJ;HARWOOD, AR;COOPER, JC
Thirty-five patients with clinically staged non-metastatic squamous carcinoma of the oesophagus were treated with radiation combined with mitomycin C, and 5-fluorouracil (5-FUra) infusion. Twenty patients were planned for a split course regimen 2250-2200 cGy in 10 fractions and chemotherapy. This dose of radiation to be repeated with another course of chemotherapy after 4 weeks rest. Fifteen patients were planned for a single course 4500-5000 cGy in 20 fractions and a single course of chemotherapy. Thirty-one patients are available for a minimum follow-up of one year, 26 patients for a minimum follow-up of 2 years. All 35 patients are included in the survival and local relapse-free analysis. Survival at one year is 47% and at 2 years 28%. The local relapse-free rate at both one and 2 years is 48%. There was an improvement in survival and local relapse-free rate for the single course regimen compared to the split course; 2 years survival 48% versus 12% (p = 0.24) local relapse-free rate 79% versus 27% (p = 0.07). All patients receiving radiation and chemotherapy were compared with historical controls treated by radiation alone. This matching procedure was done independent of knowledge of outcome (two controls were matched/case). Patients were matched for age, sex, TNM stage, and total radiation dose. There was a significant difference in survival p = 0.004 and local relapse-free rate p = 0.05 for patients receiving radiation and chemotherapy. We conclude that radiation combined with mitomycin C, and 5-FUra infusion appears to have a significant benefit compared to radiation as a single modality in the management of oesophageal squamous carcinoma.
