OSTEO-SARCOMA - 15 YEARS LATER
OSTEO-SARCOMA - 15 YEARS LATER
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DOI：
10.1056/nejm198512263132605
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
FREI, E
中科院分区：
文献类型：
--
作者：
GOORIN, AM;ABELSON, HT;FREI, E
1974年，该杂志的配对论文讨论了骨肉瘤患者在原发瘤手术后接受辅助化疗后无病生存率的改善。其中一篇论文描述了一种由长春新碱和大剂量甲氨蝶呤与亚叶酸钙组成的治疗方案1；另一篇论文讨论了阿霉素的治疗。2随附的社论赞扬了这两项研究的结果，以及Sutow等人(他们采用了四种药物联合方案)的早期发现，称它们“不仅代表了这种疾病治疗的一个里程碑，而且对一些未来的治疗也有很大的希望。”
IN 1974, companion papers in theJournaldiscussed the improved disease-free survival among patients with osteosarcoma who had received adjuvant chemotherapy after surgery for the primary tumor. One of the papers described a regimen consisting of vincristine and high-dose methotrexate with leucovorin rescue1; the other discussed treatment with doxorubicin.2The accompanying editorial praised the results of these two studies, and the earlier findings of Sutow et al.3(who employed a four-drug combination regimen) by saying that they "not only represent a milestone in the treatment of this disease but also hold great promise for the future management of some . . .