Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney.
Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney.
复制标题
吸入三氟氯乙烯和六氟丙烯对大鼠肾脏的影响。
DOI：
10.1016/0041-008x(81)90295-7
复制
发表时间：
1981
影响因子：
3.8
通讯作者：
Clayton,JW
中科院分区：
文献类型：
--
作者：
Potter,CL;Gandolfi,AJ;Nagle,R;Clayton,JW
雄性Fischer-344大鼠吸入暴露于浓度范围为100 - 540 ppm的三氟氯乙烯（CTFE）或浓度范围为380 - 1200 ppm的六氟丙烯（HFP）4.0 h。在暴露后2天内，大鼠表现出剂量相关的近端肾小管坏死、利尿、尿氟、尿乳酸脱氢酶（LDH）活性、血清肌酐和BUN增加。CTFE和HFP的毒性相似，不同之处在于（1）CTFE是更强的肾毒素，（2）HFP导致近端小管的直部和曲部部分坏死，而CTFE仅导致直部坏死。在最低接触浓度下，利尿是最敏感的毒性指标，表现为饮水量增加50%，尿液渗透压降低25%。尿LDH活性的增加与近端肾小管坏死的程度相关，在CTFE和HFP的最高浓度下增加超过100倍。在100 ppm时，CTFE诱导肾功能不全（轻度利尿），但尿LDH无显著增加，也无明显坏死。研究的所有浓度的HFP在24小时内产生坏死，4天内肾小管细胞再生明显。
Male Fischer-344 rats were subjected to 4.0 hr inhalation exposure to chlorotrifluoroethylene (CTFE) concentrations ranging from 100 to 540 ppm, or hexafluoropropene (HFP) concentrations ranging from 380 to 1200 ppm. Within 2 days following exposure, the rats exhibited dose-related proximal tubular necrosis, diuresis, increases in urinary fluoride, urinary lactic dehydrogenase (LDH) activity, serum creatinine, and BUN. The toxicities of CTFE and HFP were similar except that (1) CTFE was the more potent renal toxin and (2) HFP produced necrosis of the pars recta and pars convoluta portions of the proximal tubule, while CTFE produced necrosis of only the pars recta. At the lowest exposure concentrations, diuresis was the most sensitive index of toxicity manifesting 50% increases in water intake and 25% decreases in urine osmolality. Increases in urinary LDH activity correlated with the degree of proximal renal tubular necrosis, with greater than 100-fold increases at the highest concentrations of CTFE and HFP. At 100 ppm, CTFE induced renal dysfunction (mild diuresis), but no significant increase in urinary LDH nor necrosis were apparent. All concentrations of HFP studied produced necrosis within 24 hr postexposure, with tubular cell regeneration apparent within 4 days.