GLUCOSE-TOLERANCE AND INSULIN RELEASE, MATHEMATICAL APPROACH .1. ASSAY OF BETA-CELL RESPONSE AFTER ORAL GLUCOSE LOADING
GLUCOSE-TOLERANCE AND INSULIN RELEASE, MATHEMATICAL APPROACH .1. ASSAY OF BETA-CELL RESPONSE AFTER ORAL GLUCOSE LOADING
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DOI：
10.2337/diabetes.25.4.241
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发表时间：
1976-01-01
期刊：
影响因子：
7.7
通讯作者：
DOORENBOS, H
中科院分区：
文献类型：
--
作者：
SLUITER, WJ;ERKELENS, DW;DOORENBOS, H
从口服葡萄糖负荷后人体中葡萄糖和胰岛素之间的剂量-反应关系，可以得到β-胰岛素的可再现参数。推导出细胞反应。该参数的主要优点是，校正的胰岛素响应被定义为CIR = I. cnt。100/G（G-70）[G =葡萄糖，单位为mg/100 ml; I =免疫反应性胰岛素，单位为μ U[μ单位]/ml]，在于其独立于初始或达到的葡萄糖水平。
From the dose-response relations in humans between glucose and insulin after oral glucose loading, a reproducible parameter for .beta.-cell response was deduced. The main advantage of this parameter, corrected insulin response defined as CIR = I .cntdot. 100/G(G-70) [G = glucose, in mg/100 ml; I = immunoreactive insulin in .mu.U[.mu.units]/ml], lies in its independence from the initial or reached glucose level.