The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants.
The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants.
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DOI：
10.7150/ijms.11523
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发表时间：
2015
影响因子：
3.6
通讯作者：
Neonatal Research Network of Japan
中科院分区：
文献类型：
--
作者：
Ishikawa H;Miyazaki K;Ikeda T;Murabayashi N;Hayashi K;Kai A;Ishikawa K;Miyamoto Y;Nishimura K;Kono Y;Kusuda S;Fujimura M;Neonatal Research Network of Japan
目的：评价产前皮质类固醇（ANS）对小于胎龄儿（SGA）短期和长期结局的影响。方法：进行回顾性数据库分析。对2003年至2007年期间在日本新生儿研究网络数据库中登记的1，931例胎龄在22周至33周6天之间出生的被确定为SGA的单胎婴儿（出生体重<1，500 g）进行了短期结局和长期结局评价。结果如下：在短期结果评估组中，共有719名婴儿（37%）和344名婴儿（36%）接受了ANS治疗。ANS组和无ANS组之间的主要短期结局（校正比值比（OR）0.73; 95%置信区间（CI）0.45-1.20; P值0.22）或主要长期结局（校正OR 0.69; 95% CI 0.40-1.17; P值0.17）无显著差异。结论：我们的研究结果表明，ANS不影响短期或长期的结果，在SGA婴儿出生体重小于1500克。这项研究强烈表明，ANS的管理导致早产FGR胎儿的好处很少。
Aim: To evaluate the effect of antenatal corticosteroids (ANS) on short- and long-term outcomes in small-for-gestational age (SGA) infants. Methods: A retrospective database analysis was performed. A total of 1,931 single infants (birth weight <1,500 g) born at a gestational age between 22 weeks and 33 weeks 6 days who were determined to be SGA registered in the Neonatal Research Network Database in Japan between 2003 and 2007 were evaluated for short-term outcome and long-term outcome. Results: ANS was administered to a total of 719 infants (37%) in the short-term outcome evaluation group and 344 infants (36%) in the long-term outcome evaluation group. There were no significant differences between the ANS group and the no-ANS group for primary short-term outcome (adjusted odds ratio (OR) 0.73; 95% confidence interval (CI) 0.45-1.20; P-value 0.22) or primary long-term outcome (adjusted OR 0.69; 95% CI 0.40-1.17; P-value 0.17). Conclusions: Our results show that ANS does not affect short- or long-term outcome in SGA infants when the birth weight is less than 1500 g. This study strongly suggests that administration of ANS resulted in few benefits for preterm FGR fetuses.
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DOI：
10.1016/0002-9378(95)90222-8
发表时间：
1995-07-01
影响因子：
9.8
作者：
CROWLEY, PA
通讯作者：
CROWLEY, PA
影响因子：
7.2
作者：
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通讯作者：
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影响因子：
158.5
作者：
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通讯作者：
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作者：
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Kurita, Hiroshi
影响因子：
5.1
作者：
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通讯作者：
Fujimura, Masanori