THE ROLE OF CYTOKINES AND ADHESION MOLECULES IN THE DEVELOPMENT OF INFLAMMATORY INJURY
THE ROLE OF CYTOKINES AND ADHESION MOLECULES IN THE DEVELOPMENT OF INFLAMMATORY INJURY
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DOI：
10.1016/1357-4310(95)80019-0
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发表时间：
1995-04-01
期刊：
影响因子：
--
通讯作者：
WARD, PA
中科院分区：
文献类型：
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作者：
SHANLEY, TP;WARNER, RL;WARD, PA
临床医生经常受到患者的挑战，这些患者证明了不受控制的宿主炎症反应的不良影响。脓毒症和成人呼吸窘迫综合征(ARDS)是这种综合征的常见例子。尽管在重症监护方面取得了进展，但这些综合征的死亡率在过去20年中保持不变。为了更好地了解这种病理生理反应，并确定更特异的治疗靶点，分子生物学技术已被应用于体内炎症模型。最近的数据表明，炎症反应依赖于细胞因子和黏附分子的存在，这些黏附分子介导了中性粒细胞与内皮细胞的黏附相互作用。在这篇文章中，我们回顾了我们使用肺部炎症模型的经验，该模型提供了对导致损伤的事件的洞察。细胞因子[特别是白介素1(IL-1)和肿瘤坏死因子α(TNF-α)]和内皮细胞以及白细胞之间的黏附分子似乎协调了白细胞和内皮细胞之间的级联作用，从而导致组织损伤。
Clinicians are constantly challenged by patients who demonstrate the ill effects of an uncontrolled host inflammatory response. Patients with sepsis and adult respiratory distress syndrome (ARDS) are frequently encountered examples of this syndrome. Despite advances in intensive care, mortality from these syndromes remains unchanged over the past two decades. In order to gain a better understanding of this pathophysiological response and to identify more specific therapeutic targets, the techniques of molecular biology have been applied to in vivo inflammatory models. Recent data indicate that the inflammatory response is dependent on the presence of both cytokines and adhesion molecules that mediate neutuophil-endothelial cell adhesive interactions. In this article, we review our experience using a lung model of inflammation that has provided insight into the events leading to injury. Cytokines [particularly, interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha)], and endothelial, as well as leukocyte, adhesion molecules appear to coordinate a cascade of interactions between leukocytes and endothelial cells, which results in tissue injury.