Bayesian analyses demonstrate tissue blood volume is not decreased during acute sickle cell pain episodes: A preliminary study.
Bayesian analyses demonstrate tissue blood volume is not decreased during acute sickle cell pain episodes: A preliminary study.
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DOI：
10.3233/ch-141927
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发表时间：
2016
影响因子：
2.1
通讯作者：
Glassberg J
中科院分区：
文献类型：
--
作者：
Perry M;Simon J;Gareau D;Glassberg J
疼痛是镰状细胞病(SCD)最常见的并发症。SCD在稳态和急性疼痛期间的组织血氧测定特性没有得到很好的描述。这是一项关于SCD患者稳定期、急性疼痛和未患SCD的健康对照组的组织血氧仪特性的横断面研究。一种新的组织血氧测定仪被用来更好地解释组织色素干扰。我们假设，在急性SCD疼痛期间，疼痛区域的血容量将至少比稳定状态下减少10%。对数据的贝叶斯分析(平墩)是事先计划好的，因为预计样本量很小。样本包括14名个体(4名处于危急状态，5名处于稳定状态，5名对照组)。在SCD患者中，危象期间流向下背部的血容量较高(占组织容量的0.18%比0.14%)。贝叶斯分析得出，我们的假设(血容量将减少10%)正确的可能性为3%。在急性SCD疼痛期间，流向疼痛区域的血量不会减少。贝叶斯分析对解释小样本数据很有用，在罕见疾病的早期试验中也可能有用。
Pain is the most common complication of Sickle Cell Disease (SCD). Tissue oximetry properties in SCD during steady state and acute pain are not well described. This was a cross sectional study of tissue oximetry properties in individuals with SCD during steady state, acute pain and healthy controls without SCD. A novel tissue oximetry device was used to better account for tissue pigmentation interference. We hypothesized that during acute SCD pain, blood volume to painful areas would be at least 10% less than steady state. Bayesian analyses of the data (with flat piors) were planned a priori because of the small projected sample size. The sample included 14 individuals (4 during crisis, 5 steady state, and 5 controls). In individuals with SCD, blood volume to the lower back was higher during crisis (0.18% of tissue volume vs. 0.14%). Bayesian analyses yielded a 3% probability that our hypothesis (that blood volume would decrease by 10%) was correct. During acute SCD pain, blood volume to painful areas is not decreased. Bayesian analyses were useful for interpretation of small sample data and may have utility in early phase trials for rare diseases.