Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis
Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis
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DOI：
10.1253/circj.72.304
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Ozono, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Kadota, Koichiro;Takamura, Noboru;Ozono, Yoshiyuki
最近，通过测量肱-踝脉搏波速度和血压，建立了一种反映主动脉、股动脉和胫动脉硬度的新指标——心踝血管指数（CAVI）。方法和结果在本研究中，从普通人群中筛选了1014名日本成年人，以阐明CAVI与其他与动脉粥样硬化相关的现有标志物之间的相关性，包括颈动脉内膜-中膜厚度（CIMT）和同型半胱氨酸（HCY）。CAVI在男性和女性中都与年龄密切相关。在调整年龄和性别后，CAVI与收缩压和舒张压相关。此外，CAVI与总胆固醇、血红蛋白A1c、总HCY以及CIMT有显著相关。结论CAVI是一种合适的动脉粥样硬化筛查工具，但需要进一步研究建立一种方便有效的筛查系统。
Background A novel index, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta, femoral artery, and tibial artery, was recently developed by measuring brachial-ankle pulse wave velocity and blood pressure.Methods and Results In the present study 1,014 Japanese adults from the general population were screened to clarify the correlation between CAVI and other existing markers related to atherosclerosis, including carotid intima-media thickness (CIMT) and homocysteine (HCY). CAVI was strongly associated with age in both men and women. After adjustment for age and sex, CAVI was correlated with systolic and diastolic blood pressures. In addition, CAVI was significantly correlated with total cholesterol hemoglobin A1c and total HCY, as well as CIMT.Conclusion CAVI is an appropriate screening tool for atherosclerosis, but further studies are needed to establish a convenient and effective screening system using it.