Differential cross-tolerance between intrathecal morphine and sufentanil in the rat.
Differential cross-tolerance between intrathecal morphine and sufentanil in the rat.
复制标题
大鼠鞘内注射吗啡和舒芬太尼之间的差异交叉耐受性。
DOI：
10.1097/00000542-199012000-00012
复制
发表时间：
1990
期刊：
影响因子：
8.8
通讯作者：
Yaksh,TL
中科院分区：
文献类型：
--
作者：
Sosnowski,M;Yaksh,TL
通过皮下植入渗透泵，各组大鼠接受 7 天的恒定速率（1 微升/小时）鞘内输注盐水或两种 mu 阿片类激动剂之一：舒芬太尼（0.6 nmol/h）或吗啡（20 nmol/h）。这些浓度的吗啡和舒芬太尼在输注第一天产生了相当的接近最大热板反应潜伏期。第7天，通过建立鞘内剂量反应曲线和推注舒芬太尼和吗啡的ED50值来评估每组的耐受程度。每只输注的动物均用于单次推注。在所有情况下，与输注盐水的动物相比，输注阿片类药物都会导致吗啡和舒芬太尼的右移（ED50 增加）。然而，两种药物的转变幅度不同。因此，在注射吗啡的大鼠中，与注射盐水的动物相比，吗啡 ED50 增加了 44 倍，而舒芬太尼 ED50 则变化了 10 倍。在注射舒芬太尼的动物中，吗啡和舒芬太尼 ED50 值的变化分别增加了 9 倍和 3 倍。因此，与注射盐水的动物相比，注射吗啡的动物比注射舒芬太尼的动物观察到显着更大的转变。相反，无论动物接触哪种阿片类药物，吗啡测试的动物都比舒芬太尼测试的动物表现出更大的右移。（摘要截断为 250 字）
By means of a subcutaneously implanted osmotic pump, groups of rats received a constant-rate (1 microliter/h), 7-day intrathecal infusion of saline or one of two mu opioid agonists: sufentanil (0.6 nmol/h) or morphine (20 nmol/h). These concentrations of morphine and sufentanil yielded a comparable near maximal hot-plate response latency on day 1 of the infusion. On day 7, the magnitude of tolerance was assessed in each group by establishing intrathecal dose-response curves and ED50 values for sufentanil and morphine given as a bolus injection. Each infused animal was used for a single bolus injection. In all cases, infusion with the opioid resulted in a rightward shift (increase in ED50) for both morphine and sufentanil as compared to saline-infused animals. The magnitude of the shift, however, was different for the two drugs. Thus in morphine-infused rats, the morphine ED50 increased as compared to saline-infused animals by a factor of 44, whereas the sufentanil ED50 shifted by a factor of 10. In sufentanil-infused animals, the respective shifts in the morphine and sufentanil ED50 values were increased by a factor of 9 and 3, respectively. Thus, a significantly greater shift as compared to saline-infused animals was observed in morphine-infused than in sufentanil-infused animals. Conversely, regardless of the opioid to which the animal was exposed, morphine-tested animals showed a greater rightward shift than did sufentanil-tested animals.(ABSTRACT TRUNCATED AT 250 WORDS)