Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats
Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats
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DOI：
10.1016/j.lfs.2011.07.026
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发表时间：
2011-09-26
期刊：
影响因子：
6.1
通讯作者：
Sugimachi, Masaru
中科院分区：
文献类型：
--
作者：
Kawada, Toru;Shimizu, Shuji;Sugimachi, Masaru
目的：研究适度传出迷走神经刺激（VNS）是否通过拮抗交感神经系统而减弱颈动脉窦压力感受性反射介导的动脉压（AP）调节。在颈动脉窦压力（CSP）上施加阶梯式输入（20 Hz，2 ms，1-4 V），同时测量AP，心率（HR）和内脏交感神经活动（SNA）的反应。关键发现：多元线性回归分析表明，VNS使CSP-HR关系中的最小HR降低58.2 +/- 4.9次/min（P < 0.01）。
Aims: To examine whether moderate efferent vagal nerve stimulation (VNS) attenuates the carotid sinus baroreflex-mediated arterial pressure (AP) regulation via its antagonism to the sympathetic system.Main methods: Carotid sinus baroreceptor regions were isolated from the systemic circulation in eight anesthetized and vagotomized rats. A staircase-wise input was imposed on carotid sinus pressure (CSP) with or without efferent VNS (20 Hz, 2 ms, 1-4 V), while the responses in AP, heart rate (HR), and splanchnic sympathetic nerve activity (SNA) were measured.Key findings: A multiple linear regression analysis indicated that VNS decreased the minimum HR in the CSP-HR relationship by 58.2 +/- 4.9 beats/min (P