Synthesis of the C20-C26 building block of halichondrins via a regiospecific and stereoselective S(N)2' reaction.
Synthesis of the C20-C26 building block of halichondrins via a regiospecific and stereoselective S(N)2' reaction.
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DOI：
10.1021/ol026982p
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发表时间：
2002-11
期刊：
影响因子：
5.2
通讯作者：
C. Xie;P. Nowak;Y. Kishi
中科院分区：
文献类型：
--
作者：
C. Xie;P. Nowak;Y. Kishi
[反应：见正文]提出了一种将三磺酸酯转化为乙烯基碘的区域特异性和立体选择性的S（N）2'反应。高烯丙醇用于引导LiCu（Me）（2）的递送。
[reaction: see text] A regiospecific and stereoselective S(N)2' reaction to convert the trisylate into the vinyl iodide is presented. The homoallylic alcohol is used to direct the delivery of LiCu(Me)(2).